Results 121 to 130 of about 300,364 (303)
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source
, 2014 Includes bibliographical references.Although traditional tree methods are the simplest numerical methods for option pricing, much work remains to be done regarding their optimal parameterization and construction.
Rudd, Ralph
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Binomial Series without Binomial Coefficients
, 2023 Nowadays, the growing complexity of mathematical and computational modelling demands the simplicity of mathematical equations for solving today’s scientific problems and challenges. Also, the computational science is a rapidly growing interdisciplinary area where science, computation, mathematics, and its collaboration use advanced computing ...
openaire +1 more source
Binomial-MDN output emulating the final size distribution of a stochastic SIR model.
, 2020 (A) For random uniform sampling over β and γ a sample of the output from MDN across values for the basic reproductive number R0 = β/γ are shown in blue and the directly simulated values are shown in red.
Quentin Caudron (5042879) +3 more
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Advanced Science, EarlyView.TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao +8 more
wiley +1 more source
A Fast Algorithm for Computing Binomial Coefficients Modulo Powers of Two
The Scientific World Journal, 2013 I present a new algorithm for computing binomial coefficients modulo . The proposed method has an preprocessing time, after which a binomial coefficient with can be computed modulo in time.
Mugurel Ionut Andreica
doaj +1 more source
Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery
Advanced Science, EarlyView.A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li +9 more
wiley +1 more source
Forum of Mathematics, SigmaThe study of Koszul binomial edge ideals was initiated by V. Ene, J. Herzog, and T. Hibi in 2014, who found necessary conditions for Koszulness. The binomial edge ideal $J_G$ associated to a finite simple graph G is always generated by quadrics ...
Adam LaClair +3 more
doaj +1 more source
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Aperfeiçoamento e desenvolvimento dos gráficos combinados Shewhart-Cusum binomiais [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2010Os tradicionais gráficos de controle Shewhart são considerados efetivos na detecção de grandes mudanças
Henning, Elisa.
core