Results 181 to 190 of about 400,831 (325)

Predicting frequency distributions of blastocyst biopsy genotypes by their discrete cohort size using the binomial theorem

open access: hybrid
Thomas Huang   +5 more
openalex   +1 more source

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker   +20 more
wiley   +1 more source

Use of a negative binomial distribution to describe the presence of Sphyrion laevigatum in Genypterus blacodes

open access: gold, 2021
Patricio Peña-Rehbein   +3 more
openalex   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin   +6 more
wiley   +1 more source

Predictors of Treatment Outcome in an Early Intervention Eating Disorder Sample

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To examine baseline predictors of treatment completion and clinical outcomes in 16 to 25‐year‐olds referred for early intervention for a recent‐onset eating disorder (ED). Method Participants (n = 228; 93% female, 63% White British) were drawn from the FREED‐Up study, which evaluated First episode Rapid Early intervention for EDs ...
Karina L. Allen   +13 more
wiley   +1 more source

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