Results 41 to 50 of about 1,194,320 (236)

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Local cohomology of binomial edge ideals and their generic ideals [PDF]

, 2019
We provide a Hochster type formula for the local cohomology modules of binomial edge ideals. As a consequence we obtain a simple criterion for the Cohen-Macaulayness of these ideals and we describe their Castelnuovo-Mumford regularity and their Hilbert ...
Álvarez Montaner, Josep
core   +2 more sources

Ductile B2 Intermetallics‐Driven Strength‐Ductility Synergy in Heterolaminated Multi‐Principal Element Alloys

Advanced Science, EarlyView.
Intrinsic phase toughening transforms a brittle B2 intermetallic into a plastically deformable, load‐bearing phase, while a heterogeneous laminated architecture suppresses strain localization and interface cracking. The synergy between ductile intermetallics and mesoscale heterogeneity establishes a general design strategy for breaking the long ...
Lu Yang, Feilong Jiang, Qiming Zhuang, Dingshan Liang, Jiasi Luo, Kangjie Chu, Junhua Luan, Zengbao Jiao, Robert O. Ritchie, Fuzeng Ren   +9 more
wiley   +1 more source

Binomial edge ideals of cographs

Revista de la Unión Matemática Argentina, 2022
We determine the Castelnuovo-Mumford regularity of binomial edge ideals of complement reducible graphs (cographs). For cographs with $n$ vertices the maximum regularity grows as $2n/3$. We also bound the regularity by graph theoretic invariants and construct a family of counterexamples to a conjecture of Hibi and Matsuda.
Kahle, Thomas, Krüsemann, Jonas
openaire   +3 more sources

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

The Universal Gröbner Basis of a Binomial Edge Ideal

The Electronic Journal of Combinatorics, 2017
We show that the universal Gröbner basis and the Graver basis of a binomial edge ideal coincide. We provide a description for this basis set in terms of certain paths in the underlying graph. We conjecture a similar result for a parity binomial edge ideal and prove this conjecture for the case when the underlying graph is the complete graph.
Mourtadha Badiane, Isaac Burke, Emil Sköldberg   +2 more
openaire   +4 more sources

Voluntary Collective Action to Address Growing Agricultural Challenges in Two Countries: Experimental Insights and Commonalities

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We conducted two framed field economic experiments with citrus farmers in Florida, United States and soybean farmers in Argentina to investigate their willingness to coordinate pest and weed management efforts. Despite the contrast between these two agricultural contexts, we find striking behavioral commonalities.
Ariel Singerman, Sergio H. Lence
wiley   +1 more source

On Binomial Edge Ideals of Corona of Graphs

Mediterranean Journal of Mathematics
For a simple graph $G$, let $J_G$ denote the corresponding binomial edge ideal. This article considers the binomial edge ideal of the corona product of two connected graphs $G$ and $H$. The corona product of $G$ and $H$, denoted by $G\circ H$, is a construction where each vertex of $G$ is connected (via the coning-off) to an entire copy of $H$. This is
Hajra, Buddhadev, Sarkar, Rajib
openaire   +2 more sources

From Swarm to Individual: Emergent Individuality in Light‐Mediated Robot Collectives

Advanced Intelligent Systems, EarlyView.
Can individuality emerge from a swarm? Using nominally homogeneous phototactic robots, we show that collective light conditions reorganize robot‐level behavioral profiles. Global illumination amplifies persistent differences in state occupancy, while robot‐mounted local light cues reduce fixed differentiation and favor transient high‐switching profiles.
John Smith, Atsushi Masumori, Norihiro Maruyama, Takahide Yoshida, Takashi Ikegami   +4 more
wiley   +1 more source