Results 81 to 90 of about 3,153,646 (349)

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Unconventional machine learning of genome-wide human cancer data

, 2020
Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide perspective ...
Bajaj, Sweta R., Chittenden, Thomas W., Cilfone, Nicholas, Gamel, Omar E., Gujja, Sharvari, Gulcher, Jeffrey R., Li, Richard Y., Lidar, Daniel A.   +7 more
core   +1 more source

Geographically Weighted Negative Binomial Regression Model Predicts Wildfire Occurrence in the Great Xing’an Mountains Better Than Negative Binomial Model

Forests, 2019
Wildfire is a major disturbance that affects large area globally every year. Thus, a better prediction of the likelihood of wildfire occurrence is essential to develop appropriate fire prevention measures. We applied a global negative Binomial (NB) and a
Zhangwen Su, Hai-qing Hu, M. Tigabu, Guangyu Wang, Aicong Zeng, Futao Guo   +5 more
semanticscholar   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

Modeling tuberculosis in children under five using poisson and negative binomial regression

Desimal
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Indonesia is the country with the second highest number of tuberculosis cases after India.
Ahmad Fajri, Nur Rahmi, Putri Ayu Maharani, Muhammad Ikhlashul Amal   +3 more
doaj   +1 more source

ZERO-INFLATED NEGATIVE BINOMIAL REGRESSION FOR DIFFERENTIAL ABUNDANCE TESTING IN MICROBIOME STUDIES

Journal of Bioinformatics and Genomics, 2016
Motivation: The human microbiome plays an important role in human health and disease. The composition of the human microbiome is influenced by multiple factors and understanding these factors is critical to elucidate the role of the microbiome in health ...
Xinyan Zhang, Himel Mallick, Nengjun Yi
doaj   +1 more source

Elastic-net Regularized High-dimensional Negative Binomial Regression: Consistency and Weak Signals Detection [PDF]

, 2017
We study sparse negative binomial regression (NBR) for count data by showing non-asymptotic merits of the Elastic-net estimator. Two types of oracle inequalities are derived for the Elastic-net estimates of NBR by utilizing Compatibility Factor or Stabil
Huiming Zhang, Jinzhu Jia
semanticscholar   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

PENERAPAN REGRESI BINOMIAL NEGATIF UNTUK MENGATASI OVERDISPERSI PADA REGRESI POISSON

E-Jurnal Matematika, 2013
Poisson regression was used to analyze the count data which Poisson distributed. Poisson regression analysis requires state equidispersion, in which the mean value of the response variable is equal to the value of the variance.
PUTU SUSAN PRADAWATI, KOMANG GDE SUKARSA, I GUSTI AYU MADE SRINADI   +2 more
doaj   +1 more source

Model Regresi Binomial Negatif Terboboti Geografis Untuk Data Kematian Bayi [PDF]

, 2013
Negative binomial regression model is used to overcome the overdispersion in Poisson regression model. This model can be used to model therelationship of the infant mortality and the factors incidence. Geographical conditions, socio cultural and economic
Afri, L. E. (Lusi)
core