Results 111 to 120 of about 244,930 (304)

Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA

Molecules, 2019
The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents.
Yajun Sun, Weiwei Jin, Chenjiang Liu
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Synthesis of ureas in the bio-alternative solvent Cyrene [PDF]

, 2017
Cyrene as a bio-alternative solvent: a highly efficient, waste minimizing protocol for the synthesis of ureas from isocyanates and secondary amines in the bio-available solvent Cyrene is reported. This method eliminated the use of toxic solvents, such as
Mapesa, Kopano, Mistry, Liam, Jason E. Camp, Camp, Jason, Liam Mistry, Thomas W. Bousfield, Bousfield, Thomas W., Camp, Jason E., Kopano Mapesa   +8 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Bio-Based and Solvent-Free Epoxy Vitrimers Based on Dynamic Imine Bonds with High Mechanical Performance

Conventional epoxy thermosets, with irreversible crosslinking networks, cannot be reprocessed and recycled. Furthermore, the utilization of petroleum-based materials accelerates the depletion of non-renewable resources.
Lei Chen, Shicheng Feng, Na Ning, Gang Zhou, Zhengyan Guo, Yi Wei, Yan Li   +6 more
core   +1 more source

Solvent-free synthesis of bio-based non-isocyanate polyurethane (NIPU) with robust adhesive property and resistance to low temperature

Polymer Testing
Non-isocyanate polyurethane (NIPU) adhesives represent a cutting-edge advancement in adhesive technology, poised to significantly diminish the dependency on isocyanate-based PU within the industry.
Ping Zhang, Hanxiang Guo, Chen Qin, Hao Yuan, Yizhong Cao, Zhe Wang, Chunde Jin   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Bio-based ether solvent and ionic liquid electrolyte for sustainable sodium-air batteries

Bio-based ether solvent and ionic liquid electrolyte for sustainable sodium-air ...
Lidia Medinilla (17182501), Luis Lezama (1318113), David Mecerreyes (1375347), Pierre L Stigliano (17182498), Nagore Ortiz-Vitoriano (1331784), Juan Miguel Lopez del Amo (18101299), Cristina Pozo-Gonzalo (1296447), Jason E Bara (17182504), Maria Forsyth (13084584)   +8 more
core  

Synthesis of bio-based unsaturated polyester resins and their application in waterborne UV-curable coatings

, 2015
In this paper, three bio-based unsaturated polyesters were synthesized from itaconic acid and different diols which could be derived from renewable resources.
Zhu, Jin, Ma, Songqi, Dai, Jinyue, Wu, Yonggang, Han, Lijing, Dai, Xinyan, Liu, Xiaoqing   +6 more
core