Results 51 to 60 of about 55,725 (280)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Forces in Mechanics, 2023 This paper presents a novel study on the stability of thermo-bioconvection due to gravitactic microorganisms into an anisotropic porous fluid layer saturated with Jeffrey liquid. A Jeffrey-Darcy model along with Boussinesq approximations is utilized. The
Arpan Garg, Y.D. Sharma, Subit K. Jain
doaj +1 more source
Characterisation of water sprays using high-speed videography [PDF]
, 2016 This paper reports on the characterisation of water sprays for the purpose of modelling the effectiveness of such sprays in mitigating the impacts of wildfires on residential buildings.
Green, Alan +3 more
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
, 2012 This course introduces fluid mechanics, the study of how and why fluids (both gaseous and liquid) behave the way they do. This free course may be completed online at any time. See course site for detailed overview and learning outcomes.
The Saylor Foundation
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Effect of the Blood Vessel Viscoelasticity on Periodic Blood Pressure Wave Propagation
Journal of Fluid Science and Technology, 2009 Clinical arterial stiffness indexes such as PWV (pulse wave velocity) or PP (pulse pressure), which are obtained by analyzing blood pressure pulse waveforms in vivo, are used in the prognosis of cardiovascular diseases and thus analyses of pulse waveform
Tomoki KITAWAKI, Masashi SHIMIZU
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Computer Assisted Methods in Engineering and Science, 2011 The present issue of CAMES reflects the outcome of the 19th International Conference on Computer Methods in Mechanics (CMM 2011). This meeting was held on May 9–12, 2011, at the Warsaw University of Technology and gathered over 250 participants from 27 ...
Adam Borkowski
doaj