Results 1 to 10 of about 195,629 (193)

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Particle and Fibre Toxicology, 2022
Background Most toxicological studies on titanium dioxide (TiO2) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis, which is a variety of airspace and interstitial lung diseases caused ...
Shotaro Yamano, Yuko Goto, Tomoki Takeda, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Tatsuya Kasai, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, Yumi Umeda   +13 more
doaj   +1 more source

Applicability of Enchytraeus bulbosus as a model species in ecotoxicology and risk assessment

Ecotoxicology and Environmental Safety, 2021
Enchytraeus bulbosus is listed in the ISO and OECD standard guidelines as a possible test species of enchytraeid. However, in contrast to other listed species, its applicability in ecotoxicological studies as well as its sensitivity is widely unknown ...
Jing Yang, Xiaoqian Chen, Daqiang Yin, Haowen Yin, Ying Zhang, Min Liu, Weigang Zhao, Lu Zhang, Yanan Liu, Xichen Yang, Zhijie Zhong   +10 more
doaj   +1 more source

Role of etofenprox nanoformulation in suppression of the silver whitefly, Bemisia tabaci and its residue in eggplant fruits [PDF]

Journal of Plant Protection Research, 2023
The normal formulation of etofenprox was developed to nanoformulation and used against the adults of silver whitefly, Bemisia tabaci in eggplant fields. Three concentrations of both the normal and nanoformulations were used.
Al-kazafy Hassan Sabry, Aziza H. Mohamady, Rasha A. Sleem, Shaker M. Abolmaaty, Rania M.A. Helmy   +4 more
doaj   +1 more source

No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

Scientific Reports, 2022
With the rapid development of alternative methods based on the spirit of animal welfare, the publications of animal studies evaluating endpoints such as cancer have been extremely reduced.
Shotaro Yamano, Tomoki Takeda, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Tatsuya Kasai, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, Yumi Umeda   +13 more
doaj   +1 more source

Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers

Respiratory Research, 2023
Background Recently in Japan, six workers at a chemical plant that manufactures resins developed interstitial lung diseases after being involved in loading and packing cross-linked water-soluble acrylic acid polymers (CWAAPs).
Shotaro Yamano, Tomoki Takeda, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, Yoichiro Kobashi, Kenzo Okamoto, Takumi Kishimoto, Yumi Umeda   +15 more
doaj   +1 more source

Chloramphenicol Bioassay [PDF]

Antimicrobial Agents and Chemotherapy, 1979
An accurate plate diffusion bioassay for chloramphenicol is described, in which the fast-replicating Beneckea natriegens and 1.5% salt agar are used. Zones of inhibition were well defined after 3 h, and the limit of sensitivity of the method was around 2 μg/ml. The concurrent presence of gentamicin did not influence
R M, Bannatyne, R, Cheung
openaire   +2 more sources

Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

Scientific Reports, 2023
2-Bromopropane (2-BP) is a colorless liquid at room temperature and is used in closed systems in factories, mainly as an intermediate for medicines, pesticides, and other chemicals. However, the carcinogenicity of 2-BP is still unknown.
Yuko Goto, Arata Saito, Kenji Takanobu, Hideki Senoh, Misae Saito, Yumi Umeda, Shotaro Yamano   +6 more
doaj   +1 more source

Pollution characteristics and preliminary environmental risk assessment of typical pharmaceutical and personal care products in surface water of Qingpu District, Shanghai

环境与职业医学, 2023
BackgroundPollution prevention and control of surface water is the focus of joint prevention and control work in the Yangtze River Delta Demonstration zone. As an important part of the zone, Qingpu District of Shanghai is rich in water resources. However,
Lu SHEN, Xiaoqian CHEN, Min LIU
doaj   +1 more source

Dose–response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

Particle and Fibre Toxicology, 2022
Background In Japan, six workers handling cross-linked water-soluble acrylic acid polymer (CWAAP) at a chemical plant suffered from lung diseases, including fibrosis, interstitial pneumonia, emphysema, and pneumothorax.
Tomoki Takeda, Shotaro Yamano, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, George Daghlian, Young-Kwon Hong, Yasuhiro Yoshimatsu, Masanori Hirashima, Yoichiro Kobashi, Kenzo Okamoto, Takumi Kishimoto, Yumi Umeda   +19 more
doaj   +1 more source

Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1

mAbs, 2021
T-cell-mediated immunotherapy has generated much excitement after the success of therapeutic biologics targeting immune checkpoint molecules. Bispecific antibodies (BsAbs) that recognize two antigen targets are a fast-growing class of biologics offering ...
Weimin Chen, Madhu Pandey, Hong Sun, Andrea Rolong, Mingyan Cao, Dengfeng Liu, Jihong Wang, Lingmin Zeng, Alan Hunter, Shihua Lin   +9 more
doaj   +1 more source