Results 211 to 220 of about 124,018 (252)

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Solidagoic Acids L and M: Novel Antibacterial <i>cis</i>-Clerodane Diterpenoids Isolated from the Inflorescences of <i>Solidago gigantea</i> via a Bioassay-Guided Approach. [PDF]

Antibiotics (Basel)
Baglyas M, Bozsó Z, Móricz ÁM.
europepmc   +1 more source

Hierarchically Rough rGO/HAp Nanocoatings on SLM Ti–6Al–4 V Implants for Enhanced Biointegration

Small, EarlyView.
This study investigates HAp/rGO bioactive coatings on Ti‐6Al‐4V fixation implants fabricated by selective laser melting with systematically varied volumetric energy density to tailor the as‐built surface state. Composite coatings were deposited by electrophoretic deposition and characterized using micro‐CT, profilometry, FESEM/EDS, and detailed XPS to ...
Muhammad Usama Zaheer, Vahid Jahed, Rajveer Singh Rajaura, Fatemeh Rastegar Adib, Muhammad Hassan Razzaq, Gökhan Demirel, Mobarak Abu Mraheil, Thaqif El Khassawna, Mehmet Fatih Aycan, Yogendra Kumar Mishra   +9 more
wiley   +1 more source

Nudibranch Cadlina rumia discriminates waterborne cues to find prey and conspecifics and avoid threats. [PDF]

BMC Zool
Belmonte T, Pereira RC, Santos Erbisti R, Sudatti DB.   +3 more
europepmc   +1 more source

Fluorescence Sensing of Anions Like Adenosine 5ʹ‐Triphosphate With pH‐Gated Porous Dye‐Loaded Cerasomes

Small, EarlyView.
The development of gated systems enabling controlled pore opening offers new opportunities for sensing applications. This study explores dye loading in porous and non‐porous cerasomes and pH‐dependent ATP‐triggered gating via polyamine anchors. Porous cerasomes were synthesized using block‐co‐polymers, enabling controlled proton influx and fluorescence‐
Romane Vinot, Estela Climent, Maja Friedrich, Jérémy Bell, Knut Rurack   +4 more
wiley   +1 more source

High-Throughput Testing for Unknown Mutagens and Cytotoxica via Duplex Planar Ames-Cytotoxicity Bioassay Including Metabolic S9 Activation. [PDF]

Anal Chem
Schmidtmann K, Kayser AC, Morlock GE.
europepmc   +1 more source

Multielectron Charge Storage Enables Cascade Electrochemiluminescence in an Atomically Precise Silver Nanocluster

Small, EarlyView.
An atomically precise Ag6 nanocluster stores multiple electrons through sequential reduction reactions and releases the stored charge through successive emissive oxidation reactions with a benzoyl peroxide‐derived radical. This multielectron charge storage pathway enables an electrochemiluminescence cascade, producing a substantially more efficient ...
Zhenzhong Cai, Kai Li, Shuang‐Quan Zang, Zhifeng Ding   +3 more
wiley   +1 more source

Bacteria in stable fly (Diptera: Muscidae) feces inform foraging decisions of conspecific flies. [PDF]

J Med Entomol
Hung E, Negraeff A, Watson C, Gries R, Zamani P, Monfared A, Luke C, Gries G.   +7 more
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions. [PDF]

Proc Natl Acad Sci U S A
Nihat A, Arora P, Schmidt C, Rayner MLD, Linehan J, Brandner S, Mead S, Collinge J, Jat PS.   +8 more
europepmc   +1 more source