Results 121 to 130 of about 128,269 (307)
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Magnetic Resonance in Chemistry, EarlyView.Integration of bioactivity screening and LC–MS/MS metabolomics enabled the discovery of a new antibacterial dihydroisocoumarin from Fusarium sp. IQ‐1921. NMR‐based structural elucidation identified five related metabolites, with the new compound 1 showing the broadest activity against multidrug‐resistant bacteria. ABSTRACT Antimicrobial resistance (AMR)
Evelyn García‐Oceguera +4 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Traditional fishing with plant‐based piscicides is a global practice in decline, facing increasing restrictions. We investigated the chemical diversity of endemic Wikstroemia species historically used to stun or poison fish in Hawaiʻi. Using 1‐H‐NMR, principal component analysis, targeted HPLC, and target‐capture sequencing, we characterized compounds ...
Louise Winther +10 more
wiley +1 more source
Proposal for Development of Time-Dilution Dredged Material Bioassay using Zooplankton [PDF]
, 1976 This proposal is in reply to REFP No. DACW 39-76-R0025, for a simple, adaptable bioassay technique which can be used to evaluate the potential for toxicity that a proposed dredging activity may produce.
Bedinger, C.A., Jr.
core +1 more source
Best practices in bioassay development to support registration of biopharmaceuticals
, 2019 Biological activity is a critical quality attribute for biopharmaceuticals, which is accurately measured using an appropriate relative potency bioassay.
Matthias Naumer +14 more
core +1 more source
Pest Management Science, EarlyView.A parasitic seed germination bioassay reveals strong soil‐dependent variation in strigolactone signaling distance, controlled by physical and biological soil properties, which shapes signaling range and parasitic weed infection risk. Abstract BACKGROUND Strigolactones are root‐exuded plant metabolites acting as germination stimulants for several ...
Hammam Ziadne +2 more
wiley +1 more source
Pest Management Science, EarlyView.Two virulence strategies in Beauveria: a growth strategy characterized by rapid within‐host proliferation, and a toxin strategy involving antimicrobial activity and toxicity to insects Abstract BACKGROUND Pathogen virulence is often attributed to toxin production, yet toxins are metabolically costly and may not universally enhance fitness.
Shasha Hu +3 more
wiley +1 more source
Pest Management Science, EarlyView.Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis +8 more
wiley +1 more source
Pest Management Science, EarlyView.We compared two island populations of Bethencourtia palmensis and their culturable endophytic fungi, revealing distinct plant chemistries and a higher biopesticidal potential in the endophytic fungi from La Palma population along with high potential for the discovery of novel compounds.
Jorge Rojas López‐Menchero +4 more
wiley +1 more source
Lyophilisation of Thylakoids for Improved Handling in a Bioassay.
, 1996 The thylakoid bioassay is used to determine the effect of herbicides in water. To avoid isolation for each bioassay, lyophylisation of thylakoids for continuous, reproducible supply as bioassay material, is described.
KRAMER Gerard Nico +2 more
core +1 more source