Results 11 to 20 of about 228,987 (247)

Goodbye to the bioassay [PDF]

Toxicology Research, 2018
Abstract It is time to say goodbye to the standard two-year rodent bioassay. While a few, primarily genotoxic, compounds which are clearly associated with human cancer test positive in the bioassay, there is no science-based, sound foundation for presuming it provides either a valid broad (across different chemicals) capability for ...
Jay I. Goodman
core   +4 more sources

High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA

Science Advances, 2022
Quantitative bioassay enables the development of next-generation biodegradable polymeric nanoparticles for in vivo mRNA delivery.
Y. Rui, D. Wilson, S. Tzeng, Hannah Yamagata, Deepti Sudhakar, M. Conge, C. Berlinicke, D. Zack, Anthony Tuesca, J. Green   +9 more
semanticscholar   +1 more source

Enzyme-based digital bioassay technology - key strategies and future perspectives.

Lab on a Chip, 2022
Digital bioassays based on single-molecule enzyme reactions represent a new class of bioanalytical methods that enable the highly sensitive detection of biomolecules in a quantitative manner.
H. Noji, Yoshihiro Minagawa, H. Ueno
semanticscholar   +1 more source

Bioassay-Guided Isolation and in Silico Study of Antibacterial Compounds From Petroleum Ether Extract of Peperomia blanda (Jacq.) Kunth

, 2019
Bioassay-guided isolation protocol was performed on petroleum ether extract of Peperomia blanda (Jacq.) Kunth using column chromatographic techniques.
Najihah Mohd. Hashim (6711386), Adib A. Abdullah (6711392), Olla Sharhan (6711395), Hairin Taha (656204), Wafa M. Al-Madhagi (6711383), Abeer A. Alhadi (6711389), Nasser A. Awadh Ali (3627386), Rozana Othman (677989)   +7 more
core   +6 more sources

Exposure of Rats to Multi-Walled Carbon Nanotubes: Correlation of Inhalation Exposure to Lung Burden, Bronchoalveolar Lavage Fluid Findings, and Lung Morphology

Nanomaterials, 2023
To evaluate lung toxicity due to inhalation of multi-walled carbon nanotubes (MWCNTs) in rats, we developed a unique MWCNT aerosol generator based on dry aerosolization using the aerodynamic cyclone principle.
Tatsuya Kasai, Shoji Fukushima
doaj   +1 more source

Chloramphenicol Bioassay [PDF]

Antimicrobial Agents and Chemotherapy, 1979
An accurate plate diffusion bioassay for chloramphenicol is described, in which the fast-replicating Beneckea natriegens and 1.5% salt agar are used. Zones of inhibition were well defined after 3 h, and the limit of sensitivity of the method was around 2 μg/ml. The concurrent presence of gentamicin did not influence
R M, Bannatyne, R, Cheung
openaire   +2 more sources

Humoral cross-reactivity towards SARS-CoV-2 in young children with acute respiratory infection with low-pathogenicity coronaviruses

Journal of Clinical Virology Plus, 2022
Background: SARS-CoV-2 infection in children frequently leads to only asymptomatic and mild infections. It has been suggested that frequent infections due to low-pathogenicity coronaviruses in children, impart immunity against SARS-CoV-2 in this age ...
Nitin Dhochak, Tanvi Agrawal, Heena Shaman, Naseem Ahmed Khan, Prawin Kumar, Sushil K. Kabra, Guruprasad R. Medigeshi, Rakesh Lodha   +7 more
doaj   +1 more source

Metronidazole Bioassay [PDF]

Antimicrobial Agents and Chemotherapy, 1976
Urine from patients receiving metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitromidazole] orally or per vagina were subjected to paper chromatographic fractionation and examined for anticlostridial activity. Unmodified metronidazole and several metabolites were detected.
W T, Speck, A B, Stein, H S, Rosenkranz
openaire   +2 more sources

Neutralizing antibodies from prior exposure to dengue virus negatively correlate with viremia on re-infection

Communications Medicine, 2023
Background India is hyperendemic to dengue and over 50% of adults are seropositive. There is limited information on the association between neutralizing antibody profiles from prior exposure and viral RNA levels during subsequent infection.
Anbalagan Anantharaj, Tanvi Agrawal, Pooja Kumari Shashi, Alok Tripathi, Parveen Kumar, Imran Khan, Madhu Pareek, Balwant Singh, Chitra Pattabiraman, Saurabh Kumar, Rajesh Pandey, Anmol Chandele, Rakesh Lodha, Stephen S. Whitehead, Guruprasad R. Medigeshi   +14 more
doaj   +1 more source

Bioassay- and Chemistry-Guided Isolation of Scalemic Caged Prenylxanthones from the Leaves of Garcinia bracteata

, 2018
With bioassay- and chemistry-guided fractionation, seven new caged prenylxanthones including two scalemic mixtures, epiisobractatin (1), 13-hydroxyisobractatin (2), 13-hydroxyepiisobractatin (3), 8-methoxy-8,8a-dihydrobractatin (4), 8-ethoxy-8,8a ...
Yue-Tong Wang (4992881), Hui-Ming Hua (534567), Da-Hong Li (770554), Xin-Yu Li (1378743), Yong-Kui Jing (1546174), Zhan-Lin Li (534568), Yue-Hu Pei (737972), Sheng-Ge Li (4992878), Jiao Bai (737971), Sheng-Li Niu (1559965)   +9 more
core   +4 more sources