Results 41 to 50 of about 75,580 (245)

Evaluation of the toxicity of an oil spill conducted through bioassays using the fish Solea senegalensis

Ciencias Marinas, 2008
The toxicity produced by fuel pollutants was evaluated through bioassays using the Senegalese sole Solea senegalensis. Juveniles were exposed for 21 days to different dilutions obtained by mixing fuel extracted from the Prestige oil tanker and sediment ...
MJ Salamanca, N Jiménez-Tenorio, ML Gonzáles de Canales, TA DelValls   +3 more
doaj   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Research progress in the whole toxicity evaluation methods of industrial wastewater and their application

Gongye shui chuli
In China, the present implemented industrial wastewater discharge standards cannot objectively and correctly evaluate wastewater safety. The characteristics and application of the whole effluent toxicity evaluation methods at home and abroad were ...
GAO Pin, YU Xiaofei, YANG Jing, CHEN Xiaoqian   +3 more
doaj   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Development and calibration of a portable detection device for in vivo measurement of high-energy photon emitters incorporated by humans

Brazilian Journal of Radiation Sciences, 2018
This work presents the evaluation of the applicability and sensitivity of a portable detection device specially designed for in vivo measurement of high-energy photon emitters in the human body.
Alexandre Barbosa Soares, Mayara Nascimento Arbach, Éder Augusto de Lucena, Ana Letícia Almeida Dantas, Bernardo Maranhão Dantas   +4 more
doaj   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Using UPLC–MS/MS to Evaluate the Dissemination of Pyriproxyfen by Aedes Mosquitoes to Combat Cryptic Larval Habitats after Source Reduction in Kaohsiung in Southern Taiwan

Insects, 2020
The policy regarding mosquito control strategies in Taiwan is based on integrated vector management (IVM). The major approach is source reduction via collaboration by both residents and governments.
Ying-An Chen, Yi-Ting Lai, Kuo-Chih Wu, Tsai-Ying Yen, Chia-Yang Chen, Kun-Hsien Tsai   +5 more
doaj   +1 more source

Microfluidic Mixing with the Dynamic Control of Magnetic Actuation

Advanced Intelligent Systems, EarlyView.
Schematic illustration and flow field visualization of magnetically actuated L‐shaped microrobots displaying cooperative vortex generation for enhanced microscale mixing. The left side shows the electromagnetic actuation setup, which enables programmable control of rotational direction and frequency.
Prashant Kishor Sharma, Tsung‐Yen Lu, Chia‐Yuan Chen   +2 more
wiley   +1 more source

Drivers of insect herbivory resistance and tolerance to plant damage in the Brachypodium distachyon species complex

American Journal of Botany, EarlyView.
Abstract Premise Insect herbivory is a major biotic factor shaping plant populations and driving the evolution of defensive traits. Polyploidy (whole‐genome duplication) often induces substantial phenotypic and genotypic changes that may affect species interactions, including herbivory.
Antonio J. Manzaneda, Luisa M. Martínez, Ana Fernández‐Ocaña, Teresa Salido, Pedro J. Rey   +4 more
wiley   +1 more source

Assessment of cytotoxicity of some synthetic compounds against breast carcinoma spheroids with subsequent analysis of pro-apoptotic and gene expression

Scientific Reports
The current study examined the anticancer potential of 80 synthetic organic compounds at 50µM using in vitro two-dimensional (2D) and three-dimensional (3D) spheroids model breast adenocarcinoma (MCF7) models.
Khaled Mahmoud, Elham M. Youssef, Farid M. Sroor, Walid Fayad   +3 more
doaj   +1 more source