Results 61 to 70 of about 75,580 (245)
Drug Testing and Analysis, EarlyView.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source
Antineoplastic 4-piperidone-1-phosphonothioates with potential multi-targeted inhibitory properties
Scientific ReportsA set of 3,5-bis(ylidene)-4-piperidone-1-phosphonothioates 20a‒l was synthesized in high yields through dehydrochlorination reaction of 3,5-bis(ylidene)-4-piperidones 18a‒l and diethyl chlorothiophosphate 19 in DMF containing quantitative amounts of TEA ...
Mohamed S. Bekheit +6 more
doaj +1 more source
mSphere, 2020 To date, approximately 500 iatrogenic Creutzfeldt-Jakob disease cases have been reported worldwide, most of them resulting from cadaveric dura mater graft and from the administration of prion-contaminated human growth hormone.
Maxime Bélondrade +11 more
doaj +1 more source
Identification of Metabolites of the Dietary Supplement Ingredient 5α‐Hydroxy‐Laxogenin
Drug Testing and Analysis, EarlyView.The biotransformation of the dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated using human HepG2 cells, the rat and in silico using the online software Next‐gen E‐Resource for Drug Discovery (NERDD). We identified five metabolites generated by the human HepG2 cells of which three and an additional mono‐hydroxylated metabolite were ...
Daniel Derwand +3 more
wiley +1 more source
Frontiers in Environmental Science, 2019 There is a growing awareness among farmers about the importance of soil for sustaining crop production and soil health. Marked interests in “environmentally-friendly” soil fertilization in agriculture has attracted significant attention in the last ...
Maria Pukalchik +7 more
doaj +1 more source
Streptozotocin induced hyperglycemia in the axolotl
Developmental Dynamics, EarlyView.Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen +2 more
wiley +1 more source
Scientific ReportsSpiroindolin-2-ones with phosphonate function 17a‒t (20 analogs, 96‒72% yield) were generated by microwave synthetic methodology using azomethine cycloaddition of the appropriate 3,5-bis(ylidene)-4-piperidone-1-phosphonate 14a‒g.
Sara M. Hassan +10 more
doaj +1 more source
The macroecology of immunity: predominant influence of climate on invertebrate immune response
Ecography, EarlyView.The immune system is the primary defense against parasites. With the ever‐increasing rate of disease, epidemiologic models considering geographic variation in immune responses could prove useful. Despite increasing interest in the macroecology of parasitism and infectious diseases, we know little about the macroecology of immune responses (i.e ...
Adam Z. Hasik +9 more
wiley +1 more source
ToxinsCell-based potency assays (CBPAs) are required for the potency testing and commercial release of botulinum neurotoxin (BoNT)-based drug products. These CBPAs must account for the toxin’s biological activities while meeting regulatory guidelines for ...
F. Mark Dunning +7 more
doaj +1 more source
Julius-Kühn-Archiv, 2014 One of the possible reasons for the expansion of the alien panicoid grasses Panicum schinzii (Transvaal millet), Panicum dichotomiflorum (Fall panicum) and Panicum capillare (Witchgrass) in maize fields in Belgium might be a lower sensitivity to post ...
De Cauwer, Benny +4 more
doaj +1 more source