Results 161 to 170 of about 385,548 (309)

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications. [PDF]

Int J Mol Sci
Toumi H, Almhdie-Imjabbar A, Ibrahim N, Lespessailles E.   +3 more
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Induced Mutagenesis Improves Grain Protein and Micronutrient (Fe and Zn) Content in Spring Wheat (<i>Triticum aestivum</i> L.). [PDF]

Biology (Basel)
Gulina D, Saule K, Dinara Z, Saule A, Malika A, Sabina S, Saltanat A, Khava Y.   +7 more
europepmc   +1 more source

Internal transformation and damming regulate the longitudinal variation of DOM bioavailability in a large river

Understanding the spatial patterns of dissolved organic matter (DOM) and factors that influence them is crucial for maintaining river ecosystem functions and riverine health, considering the significant role of DOM in water quality and aquatic ecosystems.
Wang, X, Wang, W, Zhang, Q, Shu, X, Liu, W, Yang, Y   +5 more
core   +1 more source

Trophic Diversity in Duckweed: Mixotrophy, More Than the Sum of its Extremes

Advanced Science, EarlyView.
In the context of rising DOC in aquatic environments, mixotrophic duckweed may impact carbon cycling by acting as either a carbon sink, as they absorb CO2 through photosynthesis, or a carbon source, as they release CO2 through respiration of absorbed DOC, which depends on DOC concentration, light availability, temperature, and other environmental ...
Zuoliang Sun, Yan Chen, Fajun Li, Xuyao Zhao, Qingxiang Han, Hongwei Hou   +5 more
wiley   +1 more source

Fruit consumption as a gut health improving strategy to lower arsenic exposure risk from rice consumption. [PDF]

Eco Environ Health
Zhou L, Chen S, Lin X, Xue R, Zhou L, Xi J, Bao Y, Ye T, Wang P, Li H, Zhou D.   +10 more
europepmc   +1 more source

Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

, 2015
Abid Mehmood Yousaf,1 Dong Wuk Kim,1 Yu-Kyoung Oh,2 Chul Soon Yong,3 Jong Oh Kim,3 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 2College of Pharmacy, Seoul National University, Seoul,
Oh YK, Yong CS, Kim DW, Kim JO, Choi HG, Yousaf AM   +5 more
core  

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Traditional Food Systems as Nutrient Optimization Architectures: Mechanisms of Bioavailability and Dietary Resilience. [PDF]

Nutrients
Zugravu CA, Petre M, Constantin C.
europepmc   +1 more source