Results 261 to 270 of about 469,546 (342)

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

Advanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho, Su Min Kim, Jiyeon Lee, Oh Chan Kwon, Wonjin Woo, Eunji Lee, Hyo Jin Park, Yeongun Lee, So Hee Dho, Tae‐Kyung Kim, Min‐Chan Park, Richard A. Flavell, Lark Kyun Kim   +12 more
wiley   +1 more source

Pluronic P123/L64 Mixed Micelles as Immediate Release Systems to Enhance the Bioavailability of Praziquantel in Rats. [PDF]

Int J Nanomedicine
Yuan J, Su W, Gao J, Ma X, Yin R, Jia T.
europepmc   +1 more source

Preparation of sustained-release suppositories containing microencapsulated indomethacin and bioavailability of indomethacin in rabbits.

, 1987
Toshiaki Nakajima, YASUJI TAKASHIMA, KIN-ICHI IIDA, HARUMI MITSUTA, Atsushi Furuya, Masumi KOISHI   +5 more
openalex   +2 more sources

Developing Biomaterial‐Based mRNA Delivery System for Lung Disease Treatment

Advanced Science, EarlyView.
Schematic illustration of biomaterial delivery mRNA for the treatment of lung diseases. Abstract Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery.
Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi   +7 more
wiley   +1 more source

Development and evaluation of cepharanthine-β-cyclodextrin inclusion complex oral tablets for prevention and treatment of COVID-19 lung injury. [PDF]

Sci Rep
Liang D, Lv Z, Meng Z, Liu S, Gan H, Han P, Wu Z, Du L, Gu R, Dou G.   +9 more
europepmc   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

Advanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez, Maria Virginia Giolito, Sultan Al‐Siyabi, Kristian Serafimov, Florine Laloux, Emeline Dierge, Léo Aubert, Céline Guilbaud, Selena Kaye, Paula Varon, Dorothée Marchand, Hanne Vlieghe, Emmanuel Hermans, Caroline Bouzin, Davide Brusa, Christiani Andrade Amorim, Barabara Pachikian, Yvan Larondelle, Cyril Corbet, Chantal Dessy, Olivier Feron   +20 more
wiley   +1 more source

The Finite Absorption Time Concept Guiding Model Informed Drug & Generics Development in Clinical Pharmacology. [PDF]

Pharm Res
Macheras P, Tsekouras AA, Sánchez-Herrero S, Kosmidis K.   +3 more
europepmc   +1 more source

Molten‐Salt‐Mediated Synthesis of Atomic Manganese/Cobalt Catalysts on Bioceramic Microparticles for Catalytic Anti‐Osteoarthritis Treatments

Advanced Science, EarlyView.
Microparticle‐based antioxidants capable of scavenging multiple reactive oxygen species (ROS) have been developed. When retained within the articular cavity of osteoarthritic mice, Mn‐ or Co‐AKT‐MPs protect the inherent homeostasis between cartilage anabolism and catabolism, and inhibit synovial inflammation.
Ronghui Deng, Zining Zhang, Aijun Wu, Chaoqin Shu, Shitang Song, Fuzhen Yuan, Zijie Xu, Meng Yang, Jing Ye, Yifan Song, Yufang Zhu, Jia‐Kuo Yu   +11 more
wiley   +1 more source

Challenges of Using Whole-Cell Bioreporter for Assessment of Heavy Metal Bioavailability in Soil/Sediment. [PDF]

Biosensors (Basel)
Bai S, Liu Z, Xu J, Li Y, Zhang Z, Huang Z, Gustave W, Li B, Zhang X, He F.   +9 more
europepmc   +1 more source