Results 231 to 240 of about 220,549 (336)

Liver iron levels are associated with HFE-hemochromatosis genotype, diet, adiposity, and disease in the UK Biobank. [PDF]

Hepatol Commun
Lucas MR, Pilling LC, Delgado J, Williamson DS, Shearman JD, Hutchison K, Atkins JL.   +6 more
europepmc   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

The proportion of Alzheimer's disease attributable to apolipoprotein E. [PDF]

NPJ Dement
Williams DM, Heikkinen S, Hiltunen M, FinnGen, Davies NM, Anderson EL.   +5 more
europepmc   +1 more source

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies [PDF]

, 2019
Heath, Andrew C., Humphreys, Benjamin D., Madden, Pamela A. F., Wu, Haojia   +3 more
core   +1 more source

Before Symptoms Begin: Immune Activation in Preclinical ALS

Annals of Neurology, EarlyView.
Adriano Chiò, Andrea Calvo
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Social determinants of health, accelerated biological aging, and long-term health outcomes. [PDF]

Nat Commun
Li J, Li J, Xu X, Shen W, Sun Y, Fu Y, Tan X, Wang N, Qi L, Wang B, Lu Y.   +10 more
europepmc   +1 more source

Timing is everything: Expert opinion on researching epilepsy rhythms by the ILAE Task Force on Chronobiology

Epilepsia, EarlyView.
Abstract Recurrent seizures, the hallmark of epilepsy, are influenced by rhythms operating over multiple timescales. Chronobiology is the study of biological timing that aims to explain temporal patterns of events like seizures. Fueled by recent advances in genetics, computational modeling, and device engineering, the chronobiology of epilepsy is now a
Maxime O. Baud, Christophe Bernard, Birgit Frauscher, Philippa J. Karoly, Vikram R. Rao   +4 more
wiley   +1 more source

Insomnia and progression to total joint replacement in hip (41 737) and knee pain (81 958): a prospective UK biobank cohort study. [PDF]

RMD Open
Haber T, Dyer B, Klyne DM, Ferreira PH, Nicolson PJA, Lawford BJ, McCurry SM, Hall M.   +7 more
europepmc   +1 more source

Identifying direct risk factors in UK Biobank via simultaneous Bayesian-frequentist model-averaged hypothesis testing using Doublethink. [PDF]

Proc Natl Acad Sci U S A
Arning N, Fryer HR, Wilson DJ.
europepmc   +1 more source