Results 241 to 250 of about 147,982 (310)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Hot Drinks and Oesophageal Cancer: Prospective Analyses in Around 1 Million UK Adults

International Journal of Cancer, EarlyView.
ABSTRACT Studies in Asia, Africa, South America and the Middle East have consistently shown that tea or mate drunk at very high temperatures (~70°C) increases oesophageal cancer risk, but evidence is limited for drink temperatures typical of Western populations.
Keren Papier, Kezia Gaitskell, Sarah Floud, Gillian K. Reeves   +3 more
wiley   +1 more source

The 14-protein lung cancer signature: questions of prediction, specificity, and causality

Sud A, Houlston R.
europepmc   +1 more source

Clinical Relevance of BACH1 Expression in Non–Small Cell Lung Cancer

International Journal of Cancer, EarlyView.
ABSTRACT BTB and CNC homolog 1 (BACH1) is a redox‐sensitive transcription factor implicated in tumor progression, metabolic reprogramming, and therapy resistance in several cancers. However, its prognostic significance and role in therapy resistance in non–small cell lung cancer (NSCLC) remain unclear.
Jing Liu, Marc A. Schneider, Julia Held, Sabine Wrenger, Wenzhang Si, Michael Allgaeuer, Florian Eichhorn, Sabina Janciauskiene   +7 more
wiley   +1 more source

Autistic traits in the UK Biobank

Fysh M, Matlock K, Tsompanidis A, Allison C, Weir E, Radecki M, Matthews F, Warrier V, Greenberg D, Braschi S, Baron-Cohen S.   +10 more
europepmc   +1 more source

The Potential of Microbiota-Modulating Dietary Strategies in Gallstone Prevention: Evidence from 2 Large Population- Based Cohorts. [PDF]

Turk J Gastroenterol
He H, Li L, Yang X.
europepmc   +1 more source

Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors

International Journal of Cancer, EarlyView.
ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan, Nicholas Woytowich, Tian Zhao, Kiera Nguyen, Emily Mahony, Julian J. Lum, Kyle D. Duncan   +6 more
wiley   +1 more source

BMI-Based and Clinical-Obesity Trajectories and Incident Cardiovascular Disease: A Prospective UK Biobank Study. [PDF]

J Clin Med
Kwon RJ, Lim Y.
europepmc   +1 more source

Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension. [PDF]

Eur Heart J
Al-Qazazi R, Emon IM, Potus F, Martin AY, Lima PDA, Vlasschaert C, Ott BP, Chen KH, Wu D, Dasgupta A, Noordhof C, Jefferson L, Buttigieg MM, McNaughton AJM, Hindmarch CCT, Bick AG, Nichols WC, Chung WK, Hassoun PM, Damico RL, Zhu N, Shen Y, Rauh MJ, Archer SL.   +23 more
europepmc   +1 more source