Results 121 to 130 of about 20,995 (307)
Advanced Science, EarlyView.Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su +7 more
wiley +1 more source
Global Biobank Week: Toward Harmonization in Biobanking [PDF]
Biopreservation and Biobanking, 2017 Henderson, Marianne K. +6 more
openaire +3 more sources
AGING MEDICINE, EarlyView.This study highlights that physical activity, employment, and mental health significantly influence sarcopenia risk in healthy adults. Working part‐time or full‐time and exercising, especially sports like swimming, alongside good psychological health, may be associated with reduced odds of sarcopenia.
Mohammad Reza Shadmand Foumani Moghadam +11 more
wiley +1 more source
, 2016 Medical research increasingly relies on collections of donated human tissue, such as DNA samples, blood samples and solid organs and tissues. These collections of donated samples – referred to as biobanks, biorepositories or tissue banks – can be used in
Kerridge, I, Lipworth, W, Mason, P.H.
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Biomarkers of Sarcopenia: Current Status and Future Perspectives
AGING MEDICINE, EarlyView.In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo +6 more
wiley +1 more source
NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
wiley +1 more source
Translational Gap in Biomarker Discovery: Tumor Surface Markers Rarely Mirror Circulating Levels
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Background Tumor‐associated cell surface proteins are frequently proposed as circulating biomarkers for colorectal cancer (CRC) based on their high tumor expression. However, many candidates identified through tissue‐based analyses fail to translate into clinically useful biomarkers.
Junko Mukohyama +9 more
wiley +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
, 2017 This review critically discussed three ethical concerns of biobanks: consent, altruism, and benefit. Informed consent, altruism, and benefit are issues that must be address in an ethical manner in relation to the operation of biobanks.
Alanazi, Mohammed, Alanazi, Mansour
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AI Powered Biobanks From Static Archives to Dynamic Discovery Engines
Advanced Intelligent Discovery, EarlyView.Large language models (LLMs) provide a potential framework for transforming biobanks from static data repositories into intelligent discovery engines. By enabling unified representation and analysis of multimodal biomedical data, LLM‐based systems facilitate dynamic risk prediction, biomarker identification, and mechanistic interpretation, thereby ...
Wenzhen Yin +5 more
wiley +1 more source