Results 221 to 230 of about 32,321 (308)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study. [PDF]

PLoS Genet
Lin YJ, Liu TY, Yang JS, Li JP, Chiou JS, Lu HF, Ariyoshi K, Hikino K, Terao C, Chou CH, Liang WM, Chou IC, Lin TH, Liao CC, Huang SM, Tsai FJ.   +15 more
europepmc   +1 more source

Cardiovascular disease incidence and cancer risk in two large European prospective cohorts

International Journal of Cancer, EarlyView.
What's New? Cardiovascular disease (CVD) and cancer share risk factors and biological mechanisms, raising questions about potential associations between the two, particularly regarding CVD duration and cancer onset. Whether CVD influences subsequent cancer risk, however, remains inconclusive.
Emma Fontvieille, Vivian Viallon, Laia Peruchet‐Noray, Quan Gan, N. Charlotte Onland‐Moret, Yvonne Koop, Anne Tjønneland, Nicola Patricia Bondonno, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Catarina Schiborn, Calogero Saieva, Vittorio Simeon, Claudia Agnoli, Rosario Tumino, Fulvio Ricceri, Leila Luján‐Barroso, Maria‐José Sánchez, Conchi Moreno‐Iribas, Konstantinos K. Tsilidis, Marc J. Gunter, Adam Butterworth, Elio Riboli, Heinz Freisling, Pietro Ferrari   +25 more
wiley   +1 more source

Construction and Application of a Biological Sample Library Information Management System Based on a Data Governance System in China. [PDF]

Healthc Inform Res
Wang K, Fu X, Chen Y, Yu J, Xv N, Peng J, Yang K.   +6 more
europepmc   +1 more source

Transcriptome‐Based Classification of Resected Pancreatic Ductal Adenocarcinoma Enhances Prognostic Modelling Accuracy of Overall Survival Following Adjuvant Treatment

International Journal of Cancer, EarlyView.
Outcomes after resection of pancreatic ductal adenocarcinoma remain highly variable, and existing prognostic models lack sufficient accuracy. Here, the authors aimed to improve survival prediction by integrating transcriptome‐based subtyping into a validated clinical model and applying it to a multicenter real‐world cohort of fresh‐frozen resection ...
Marjolein F. Lansbergen, Vincent R. Lanting, Paul Manoukian, Marc G. Besselink, Geert Kazemier, Ignace H. J. T. de Hingh, Mike S. L. Liem, Casper H. J. van Eijck, Erwin van der Harst, Vincent E. de Meijer, Ronald M. van Dam, Martijn W. J. Stommel, Jan Koster, Michael W. T. Tanck, Arantza Fariña Sarasqueta, Joanne Verheij, Frederike Dijk, Johanna W. Wilmink, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven, for the Dutch Pancreatic Cancer Group   +20 more
wiley   +1 more source

Exploring perspectives of interest-holders on the use of health and genomic data from deceased participants in research: An updated systematic review. [PDF]

J Genet Couns
Kucharska K, Ali AH, Moriarty F.
europepmc   +1 more source

Mental Health Conditions and Incident Cancer: A Prospective Cohort Study of 402,255 UK Biobank Participants

International Journal of Cancer, EarlyView.
Evidence suggests a potential association between mental health conditions and cancer risk, yet previous studies were limited by small samples and the use of self‐reported measures. Using data from the UK Biobank's large‐scale prospective population cohort over a median follow‐up of 13.4 years, this analysis demonstrates associations between depression,
Mohammed Sherif Amin, Solange Parra‐Soto, Ziyi Zhou, Shinya Nakada, Ike Dhiah Rochmawati, Carlos Celis‐Morales, Nancy Meligy, Jill P. Pell, Frederick K. Ho   +8 more
wiley   +1 more source

Streamlining protocols for the establishment of a physical biobank of respiratory viruses in the Philippines. [PDF]

J Transl Med
Reyes-Haygood SJ, Rala-Ramos L, Balgos Pada-On JE, Pigao EC, Nicole Perreras MA, Tongol AF, Leon A, Alonzo-Dimamay MT.   +7 more
europepmc   +1 more source

Associations of Outdoor Air Pollution With Incidence of Cancers Other Than Lung Cancer in a Large US Prospective Cohort

International Journal of Cancer, EarlyView.
Associations between outdoor air pollution and cancers other than lung cancer remain unclear, particularly in the context of tobacco use. Here, the authors assessed possible links between ambient air pollutant exposure and incidence of 20 non‐lung cancers among adults followed over a 25‐year period in the United States.
W. Ryan Diver, Lauren R. Teras, Emily L. Deubler, Alpa V. Patel, Michelle C. Turner   +4 more
wiley   +1 more source

Biosample Donation Intentions of Patients with Infectious Disease Based on the Theory of Planned Behavior: A Qualitative Study. [PDF]

Infect Drug Resist
Wang W, Pan M, Liu Y, Wang J, Zhou J, Zhao Y, Xie P, Dong H, Yi C, Sun H.   +9 more
europepmc   +1 more source