Results 181 to 190 of about 3,414,938 (258)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Impact of Postharvest Oxalic Acid Treatments on Quality Properties and Biochemical Composition of Medlar (<i>Mespilus germanica</i> L.) Fruit. [PDF]

Food Sci Nutr
Çolak AM, Gündoğdu Ö, Aglar E, Sezgin N, Orman E, Gundogdu M.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Growth Performance and Biochemical Composition of Black Soldier Fly Larvae (<i>Hermetia illucens</i>) Reared on Diets Containing Similar Crude Protein Content. [PDF]

Insects
Naser El Deen S, van Rozen K, Elissen H, van Wikselaar P, Fodor I, van der Weide R, Hoek-van den Hil E, Rezaei Far A, Veldkamp T.   +8 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Influence of salicylic acid on plant defense, growth and biochemical composition of Salix alba infected with Lymantria obfuscata in Kashmir. [PDF]

Sci Rep
Wagay OA, Mugloo JA, Hussain B, Pala NA, Parrey GN, Rafeeq J.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Seasonality: The Driving Force Behind the Antimicrobial and Antioxidant Activities and Biochemical Composition of <i>Ericaria selaginoides</i> Extracts, with Minimal Effect of High Hydrostatic Pressure Pretreatment. [PDF]

Mar Drugs
Ray S, Hortos M, Casal-Silva A, Cueto M, Aymerich T.   +4 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Optimizing nitrogen and sulfur supplementation for enhanced growth and biochemical composition in Solanum lycopersicum under hydroponic conditions. [PDF]

Sci Rep
Anjum MA, Hosen ME, Sraboni FS, Ahmed NU, Goshwami A, Islam MA, Acharjee UK, Alqahtani T, Sindi ER, Tóth Z, Zaman R, Zaki MEA.   +11 more
europepmc   +1 more source