Results 21 to 30 of about 5,413 (240)

KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics

Frontiers in Physiology, 2021
Indigenous peoples of the Americas are proficient in botanical medicine. KCNQ family voltage-gated potassium (Kv) channels are sensitive to a variety of ligands, including plant metabolites.
Geoffrey W. Abbott, Kaitlyn E. Redford, Ryan F. Yoshimura, Rían W. Manville, Luiz Moreira, Kevin Tran, Grey Arena, Alexandra Kookootsedes, Emma Lasky, Elliot Gunnison   +9 more
doaj   +1 more source

Bioelectric fields at the beginnings of life [PDF]

, 2022
The consensus on the origins of life is that it involved organization of prebiotic chemicals according to the underlying principles of thermodynamics to dissipate energy derived from photochemical and/or geochemical sources.
Bell, Jimmy D., Guy, Geoffrey W., Bell, Jimmy D, Guy, Geoffrey W, Nunn, Alistair V.W., Nunn, Alistair VW   +5 more
core   +1 more source

An allosteric modulator activates BK channels by perturbing coupling between Ca2+ binding and pore opening

Nature Communications, 2022
Ca2+ activated BK channels are important for neural and muscle function. Here authors use a compound, BC5, to show that the interface between the cytosolic and voltage sensing domains is a major allosteric pathway for Ca2+ binding to open the channel.
Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L. Magleby, Jonathan R. Silva, Jianhan Chen, Xiaoqin Zou, Jianmin Cui   +12 more
doaj   +1 more source

Microbial electrochemical systems for bioelectricity generation: Current state and future directions

Results in Engineering, 2023
Increasing environmental pollution is a major concern, driven by fossil fuel consumption and growing energy demands. Energy production from various waste materials such as wastewater and sludge, could be proposed as a practical and appropriate solution ...
Farzaneh Mohammadi, G. Reza Vakili-Nezhaad, Nabeel Al-Rawahi, Sahar Gholipour   +3 more
doaj   +1 more source

Bioelectricity Generated by Microbial Fuel Cells from Spearmint (Mentha Spicata) and Ribbon Plant (Chlorophytum Comosum)

Chemical Engineering Transactions, 2023
Clean energy such as bioelectricity, a sustainable energy, obtains electricity associated with biological processes that do not generate greenhouse gases.
Eusterio H. Acosta Suasnabar, Milagros Y. Gomez De La Cruz, Paola Y. Medina Simeon, Wilber S. Quijano Pacheco, Carlos A. Castaneda-Olivera, Elmer Benites Alfaro   +5 more
doaj   +1 more source

Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain

Nature Communications, 2023
There are currently no drugs known to rescue the function of Kv1.1 voltage-gated potassium channels carrying loss-of-function sequence variants underlying the inherited movement disorder, Episodic Ataxia 1 (EA1).
Rían W. Manville, J. Alfredo Freites, Richard Sidlow, Douglas J. Tobias, Geoffrey W. Abbott   +4 more
doaj   +1 more source

Bioelectricity in Developmental Patterning and Size Control: Evidence and Genetically Encoded Tools in the Zebrafish Model

Cells, 2023
Developmental patterning is essential for regulating cellular events such as axial patterning, segmentation, tissue formation, and organ size determination during embryogenesis.
Martin R. Silic, GuangJun Zhang
doaj   +1 more source

Case report: A novel loss-of-function pathogenic variant in the KCNA1 cytoplasmic N-terminus causing carbamazepine-responsive type 1 episodic ataxia

Frontiers in Neurology, 2022
Episodic ataxia is an umbrella term for a group of nervous system disorders that adversely and episodically affect movement. Episodes are recurrent, characterized by loss of balance and coordination and can be accompanied by other symptoms ranging from ...
Rían W. Manville, Richard Sidlow, Geoffrey W. Abbott   +2 more
doaj   +1 more source

Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

Frontiers in Cell and Developmental Biology, 2022
Pluripotent stem cell-derived organoid models of the central nervous system represent one of the most exciting areas in in vitro tissue engineering. Classically, organoids of the brain, retina and spinal cord have been generated via recapitulation of in ...
Michelle O’Hara-Wright, Michelle O’Hara-Wright, Sahba Mobini, Anai Gonzalez-Cordero, Anai Gonzalez-Cordero   +4 more
doaj   +1 more source

Direct neurotransmitter activation of voltage-gated potassium channels

Nature Communications, 2018
M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine.
Rían W. Manville, Maria Papanikolaou, Geoffrey W. Abbott   +2 more
doaj   +1 more source