Results 71 to 80 of about 224,767 (344)

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and peripheral arterial disease. Clopidogrel requires metabolic activation by the cytochrome P450 enzyme CYP2C19 to be effective.
Cinzia Dello Russo, Iain Frater, Rebecca Kuruvilla, Stefanie Lip, Hannah O'Neill, Kerry Burke, Vicky Chaplin, Alexander S. F. Doney, Salim Elyas, Nicholas Greaves, Sophie Harding, David Hargroves, Judith Hayward, Dyfrig A. Hughes, Tom A. T. Hughes, Sree Kondapally, Patrick Mok, Aaron Peace, Imran Rafi, Simon Ray, Vicky Stinton, Luigi Venetucci, Munir Pirmohamed   +22 more
wiley   +1 more source

Improvement of EPO Transgene Detection From Polymeric Dried Blood Spots for Antidoping Application

Drug Testing and Analysis, EarlyView.
This article presents an optimized protocol for gene doping detection. Starting from one spot DBS (20 μL), concentrated DNA was obtained and real‐time PCR parameters were adjusted for increased detection. Robust detection of 5000 copies/mL of transgene was validated for polymeric device TASSO M‐20.
Alexandre Marchand, Ingrid Roulland, Magnus Ericsson   +2 more
wiley   +1 more source

Bioethics as an Ethics of Extinction [PDF]

S&F_scienzaefilosofia.it, 2023
Bioethics and the Ethics of Extinction This article explores the idea of rethinking bioethics in terms of an Ethics of extinction. After showing the centrality to contemporary ethical debates of extinction, the article shows how bioethics was the first ...
Lo Sapio, Luca
doaj  

Towards Pluri-Perspectivism Bioethics [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2013
Why are we lawyers still dealing with Bioethics? Who has given us the opportunity to, out of our own self-sufficiency, which legal doctrine and practice have enabled, make a journey towards the field of Bioethics? The separation of the law from Bioethics,
Đurđić Vojislav, Trajković Marko
doaj   +1 more source

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites

Drug Testing and Analysis, EarlyView.
Well‐characterized, chemically synthesized molecules related to LGD‐4033 metabolism were used as analytical standards for the analysis of LGD‐4033 post‐administration urine samples. This approach offered further insights into LGD‐4033 metabolism, providing solid experimental proof for the structure of important previously reported metabolites and ...
Yiannis S. Angelis, Panagiotis Sakellariou, Mario Thevis, Andreas Thomas, Michael Petrou, Emmanuel N. Pitsinos   +5 more
wiley   +1 more source

Do We – and Should We – Have a Canadian Bioethics?

Canadian Journal of Bioethics, 2020
Do we have a genuinely Canadian bioethics – and not only a practice of bioethics in Canada? This question, and this paper, are about the connection between bioethics and the actual healthcare, research, and public health experiences of Canadians.
Eric Racine
doaj   +1 more source

Neoliberalising bioethics: Bias, enhancement and economistic ethics [PDF]

, 2008
In bioethics there is an ongoing debate about the ethical case for human enhancement through new biomedical technologies. In this debate there are both supporters and opponents of human enhancement technologies such as genetic improvements of cognitive ...
Birch, Kean
core   +1 more source

A Robust Multistep Digestion Method for Microplastics Detection in Human Tissue by MicroRaman Analysis

Drug Testing and Analysis, EarlyView.
A unified digestion protocol for human biological samples has been developed for microplastics analysis by microRaman Spectroscopy. ABSTRACT The presence of microplastics (MPs) in human tissues has raised growing concerns, necessitating robust protocols for their reliable extraction and analysis.
Jennifer P. Pascali, Lucio Litti, Arianna Fornasari, Arianna Giorgetti, Michele Pozzebon, Rossella Barone, Antonio Ragusa, Paolo Fais   +7 more
wiley   +1 more source

Research hotspots and development trends of medical ethics and bioethics [PDF]

International Journal of Ethics and Society
Introduction: The objective is to examine the conceptual structure of research related to medical ethics and bioethics in the Web of Science database and to identify the sub-domains and important dimensions of these concepts.
Saleh Rahimi, Faramarz Soheili, Asie Moradi   +2 more
doaj  

Docile Bodies: Transnational Research Ethics as Biopolitics [PDF]

, 2009
This essay explores the claim that bioethics has become a mode of biopolitics. It seeks to illuminate one of the myriad of ways that bioethics joins other institutionalized discursive practices in the task of producing, organizing, and managing the ...
Lysaught, M. Therese
core   +2 more sources