Results 161 to 170 of about 475,267 (360)

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part3 [PDF]

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Timothy Sackton (3549617), Baker, Allan, Grayson, Phil, Clamp, Michele, Phil Grayson (3294831), Edwards, Scott, Alison Cloutier (3242235), Scott Edwards (587488), Cloutier, Alison, Michele Clamp (6557069), Allan Baker (6323504), Sackton, Timothy   +11 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

A structural model of the active ribosome-bound membrane protein insertase YidC

eLife, 2014
The integration of most membrane proteins into the cytoplasmic membrane of bacteria occurs co-translationally. The universally conserved YidC protein mediates this process either individually as a membrane protein insertase, or in concert with the SecY ...
Stephan Wickles, Abhishek Singharoy, Jessica Andreani, Stefan Seemayer, Lukas Bischoff, Otto Berninghausen, Johannes Soeding, Klaus Schulten, Eli O van der Sluis, Roland Beckmann   +9 more
doaj   +1 more source

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part14 [PDF]

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Timothy Sackton (3549617), Phil Grayson (3294831), Alison Cloutier (3242235), Scott Edwards (587488), Michele Clamp (6557069), Allan Baker (6323504)   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

‌RNA secondary structure and qRT-PCR analyses pertained to expressed anti-CD25 CAR in NK-92 cell line

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Tumor-infiltrating regulatory T (TI-Treg) cells perform the significant function in cancer immune escape. In this study, the third generation CAR construct was designed against human CD25 antigen, the significant cell surface ...
Moein Dehbashi, Zohreh Hojati, Majid Motovali-bashi, Mazdak Ganjalikhani-Hakemi   +3 more
doaj  

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part4 [PDF]

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Timothy Sackton (3549617), Phil Grayson (3294831), Alison Cloutier (3242235), Scott Edwards (587488), Michele Clamp (6557069), Allan Baker (6323504)   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Fish community assessment with eDNA metabarcoding: effects of sampling design and bioinformatic filtering

, 2017
Species richness is a metric of biodiversity that represents the number of species present in a community. Traditional fisheries assessments that rely on capture of organisms often underestimate true species richness.
Nathan T. Evans, Yiyuan Li, M. Renshaw, Brett P. Olds, K. Deiner, C. Turner, C. Jerde, D. Lodge, G. Lamberti, M. Pfrender   +9 more
semanticscholar   +1 more source

Bioinformatic Methods and Bridging of Assay Results for Reliable Tumor Mutational Burden Assessment in Non-Small-Cell Lung Cancer

Molecular Diagnosis & Therapy, 2019
Tumor mutational burden (TMB) has emerged as a clinically relevant biomarker that may be associated with immune checkpoint inhibitor efficacy. Standardization of TMB measurement is essential for implementing diagnostic tools to guide treatment.
Han Chang, A. Sasson, S. Srinivasan, R. Golhar, D. Greenawalt, W. Geese, G. Green, K. Zerba, S. Kirov, J. Szustakowski   +9 more
semanticscholar   +1 more source