Results 151 to 160 of about 475,267 (360)

Genome-wide analysis of the WRKY gene family and its response to abiotic stress in buckwheat (Fagopyrum tataricum)

Open Life Sciences, 2019
The WRKY gene family is an ancient plant transcription factor (TF) family with a vital role in plant growth and development, especially in response to biotic and abiotic stresses. Although many researchers have studied WRKY TFs in numerous plant species,
He Xia, Li Jing-jian, Chen Yuan, Yang Jia-qi, Chen Xiao-yang   +4 more
doaj   +1 more source

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part1 [PDF]

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Timothy Sackton (3549617), Baker, Allan, Grayson, Phil, Clamp, Michele, Phil Grayson (3294831), Edwards, Scott, Alison Cloutier (3242235), Scott Edwards (587488), Cloutier, Alison, Michele Clamp (6557069), Allan Baker (6323504), Sackton, Timothy   +11 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Promising Potential of Lonchocarpus utilis against South American Myasis

Plants, 2019
Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare.
Carmen X. Luzuriaga-Quichimbo, José Blanco-Salas, Carlos E. Cerón-Martínez, Juan Carlos Alías-Gallego, Trinidad Ruiz-Téllez   +4 more
doaj   +1 more source

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part12 [PDF]

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Timothy Sackton (3549617), Phil Grayson (3294831), Alison Cloutier (3242235), Scott Edwards (587488), Michele Clamp (6557069), Allan Baker (6323504)   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Characterization of the function and clinical value of ERCC family genes in lung adenocarcinoma

Frontiers in Oncology
IntroductionERCC genes, responsible for encoding enzymes involved in base excision repair, have been implicated in various cancers, contributing to chemoresistance.
Zhimin Lu, Guoxin Hou
doaj   +1 more source

Supplementary data: CR1 retroelement insertions bioinformatic pipeline part5 [PDF]

, 2019
Supplementary data: CR1 retroelement insertions bioinformatic pipeline ...
Scott V. Edwards (7850300), Phil Grayson (3294831), Alison Cloutier (3242235), Timothy B. Sackton (8031731), Michele Clamp (6557069), Allan J. Baker (8031734)   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

Leukemia, 2019
Assessment of clonality, marker identification and measurement of minimal residual disease (MRD) of immunoglobulin (IG) and T cell receptor (TR) gene rearrangements in lymphoid neoplasms using next-generation sequencing (NGS) is currently under intensive
H. Knecht, T. Reigl, M. Kotrová, F. Appelt, P. Stewart, V. Bystrý, A. Krejci, A. Grioni, K. Pal, K. Stranska, K. Plevová, J. Rijntjes, S. Songia, M. Svatoň, E. Froňková, J. Bartram, B. Scheijen, D. Herrmann, R. García-Sanz, J. Hancock, J. Moppett, J. V. van Dongen, G. Cazzaniga, F. Davi, P. Groenen, M. Hummel, E. Macintyre, K. Stamatopoulos, J. Trka, A. Langerak, D. Gonzalez, C. Pott, M. Brüggemann, N. Darzentas   +33 more
semanticscholar   +1 more source