Results 11 to 20 of about 58,954 (218)
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
G Protein-Coupled Receptor Kinases Take Central Stage
Cells, 2022 The relevance of the family of G protein-coupled receptor kinases (GRKs) is based on its key participation in the regulation and intracellular dynamics of the largest family of membrane receptors, namely G protein-coupled receptors (GPCRs) [...]
Federico Mayor, Cristina Murga
doaj +1 more source
Sfrp1 deficiency makes retinal photoreceptors prone to degeneration
Scientific Reports, 2020 Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity.
Elsa Cisneros +10 more
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Biologia do cancro do pulmão: conceitos actuais
Revista Portuguesa de Pneumologia, 2002 RESUMO: No presente artigo de revisão o autor relata os conhecimentos actuais sobre a biologia celular e molecular do cancro do pulmão, relacionandoos, sempre que possível, com as respectivas implicações diagnósticas, prognósticas e terapêuticas.REV PORT
Renato Sotto-Mayor
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Revista Mexicana de Biodiversidad, 2019 El libro de Edna Suárez relata los acontecimientos que llevaron a una mejor comprensión de las bases moleculares de la evolución, principalmente entre las décadas de 1950 y 1970.
Juan J. Morrone
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Cadernos CajuínaAs estratégias de ensino que utilizam ferramentas de Bioinformática na compreensão da Biologia Molecular e de suas aplicações sociais configuram-se como recursos fundamentais na formação inicial de professores de Ciências Biológicas.
Rian da Silva Oliveira +2 more
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Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source