Results 191 to 200 of about 86,377 (263)

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Genomics, Molecular Taxonomy, and Functional Genetics: Insights from a Diverse Collection of Studies. [PDF]

Genes (Basel)
Lorite P, Figueras A.
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Cadmium-Induced Neuroendocrine Alterations: Gene Expression of the Kisspeptin-GnRH Axis and Delayed Puberty in Male Rats. [PDF]

Toxics
Arteaga-Silva M, Cornejo de la Concha EM, Landero-Huerta DA, Montes S, Rojas-Castañeda JC, Vigueras-Villaseñor RM, Hernández-Rodríguez J, Marín de Jesús S, Pérez-Aguirre SG, López-Ruíz RT, Arrieta-Cruz I.   +10 more
europepmc   +1 more source

Shelters or ecological traps? Context‐dependent effects of nestboxes on breeding success in a colonial raptor

Ibis, EarlyView.
Artificial breeding structures, such as nestboxes, can potentially influence the population size and conservation status of bird species relying on heavily human‐modified environments such as agroecosystems and urban areas. However, the effectiveness of these interventions may vary, as artificial structures could attract individuals to suboptimal ...
Alejandro Corregidor‐Castro, Alessandro Berlusconi, Jacopo G. Cecere, Sara Cioccarelli, Claudia De Battisti, Andrea Romano, Diego Rubolini, Andrea Pilastro, Michelangelo Morganti   +8 more
wiley   +1 more source

More tools to uncover cancer cells. [PDF]

Mol Ther Oncol
Pignataro MF, Santos J.
europepmc   +1 more source

Editorial Expression of Concern: Two novel human anti-ErbB2 immunoagents are active on trastuzumab-resistant tumours. [PDF]

Br J Cancer
Gelardi T, Damiano V, Rosa R, Bianco R, Cozzolino R, Tortora G, Laccetti P, D'Alessio G, De Lorenzo C.   +8 more
europepmc   +1 more source

Correction: A real-time PCR assay for detection of low <i>Pneumocystis jirovecii</i> levels. [PDF]

Front Microbiol
Ruiz-Ruiz S, Ponce CA, Pesantes N, Bustamante R, Gatti G, San Martin V, Gutierrez M, Bórquez P, Vargas SL, Magne F, Calderón EJ, Pérez-Brocal V, Moya A.   +12 more
europepmc   +1 more source