Results 81 to 90 of about 176,610 (307)

One‐Pot Synthesis of a Small Synthetic Ligand for Antibody Purification

Biotechnology and Bioengineering, EarlyView.
One‐pot liquid‐phase synthesis of the synthetic ligand B1Al2A2 enables controllable ligand density and efficient capture of IgG and IgY with high recovery and purity, streamlining small‐ligand affinity purification workflows. ABSTRACT The development of synthetic affinity ligands offers a cost‐effective alternative to traditional biological ligands ...
Carolina Mota Natal, Catarina Domingos, André Nascimento, José Mendes, Afonso B. Ruiz, Ana Margarida Gonçalves Carvalho Dias, Luisa M. Ferreira, Cristina Peixoto, Ana Cecília Afonso Roque   +8 more
wiley   +1 more source

REGULATION OF AMYLOIDOGENESIS BY THE GLIAL MEMBRANE-BINDING PROTEIN APOLIPOPROTEIN D

IBRO Neuroscience Reports, 2023
Jorge Mondejar-Duran, Beatriz Duran, Diego Sanchez, Maria Dolores Ganfornina Alvarez   +3 more
doaj   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

New insights into McArdie disease : characterization of the murine model and development of new diagnosis and therapeutic approaches / [PDF]

, 2015
La malaltia de McArdle (glicogenosis tipus V), és la glicogenosis muscular més freqüent i està causada per la manca de la isoforma muscular de la glicogen fosforilasa.
Brull Cañagueral, Astrid, Meseguer Navarro, Anna, Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular   +2 more
core  

Pulmonary development in Squamata: Insights from embryonic studies using micro‐CT

Developmental Dynamics, EarlyView.
Abstract Background Pulmonary development in tetrapods is a complex process, especially within squamates, where single‐chambered, transitional, and multi‐chambered lungs can be found in adult animals. While the embryological development of the respiratory system of lizards and snakes was studied in a number of species between the 1830s and 1940s, the ...
Barbara G. Champini, Raul E. Diaz Jr., Emma R. Schachner, Wilfried Klein   +3 more
wiley   +1 more source

Identifiquen el paper clau d'un gen per a la supervivència neuronal [PDF]

, 2012
Investigadors de l'Institut de Neurociències de la Universitat Autònoma de Barcelona (INc-UAB) han identificat el paper fonamental que juga un gen, Nurr1, en la supervivència neuronal associada a l'activitat sinàptica.
Departament de Bioquímica i de Biologia Molecular, Rodríguez Álvarez, José, Universitat Autònoma de Barcelona. Institut de Neurociències   +2 more
core  

Stereochemical Modulation of Palladacyclopentadienyl Complexes Bearing Diphosphine Ligands: A Key to Enhanced DNA Interaction and Anticancer Activity

European Journal of Inorganic Chemistry, EarlyView.
A modular library of structurally robust palladacyclopentadienyl Pd(II) complexes bearing achiral and chiral diphosphines was developed, revealing a strong influence of diphosphine design and ligand chirality on cytotoxicity and selectivity against ovarian cancer cells, including platinum‐resistant models.
Stefania Mautone, Martina Scianna, Isabella Caligiuri, Laura Orian, Pablo Nogara, Nicola Demitri, Flavio Rizzolio, Thomas Scattolin   +7 more
wiley   +1 more source

Selection and validation of reference genes suitable for gene expression analysis by Reverse Transcription Quantitative real-time PCR in Acinetobacter baumannii

Scientific Reports
Acinetobacter baumannii is a Gram-negative bacterium considered an emerging multi-drug-resistant pathogen. Furthermore, this bacterium can survive in extreme environmental conditions, which makes it a frequent cause of nosocomial infection outbreaks ...
Paloma Aparecida Alves de Oliveira, Juliana Baboghlian, Clarissa Orandina Aparecida Ramos, Alquiandra Stefani Ferreira Mançano, Andréia de Melo Porcari, Raquel Girardello, Lúcio Fábio Caldas Ferraz   +6 more
doaj   +1 more source

Diabetes mellitus y barrera hematorretiniana. Análisis in vitro de la expresión de proteínas de tight junction y su traducción funcional. Implicaciones terapéuticas [PDF]

, 2015
El edema macular diabético (DME) es una de las primeras causas de disminución de la agudeza visual en pacientes con retinopatía diabética (DR). La rotura de la barrera hematorretiniana (BHR) debido a la disrupción de las tight junctions (TJ) es el ...
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular, Villarroel Fandos, Marta   +1 more
core   +1 more source

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source