Results 241 to 250 of about 302,285 (314)

Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence? [PDF]

Allergy
Gangemi S, Manti S, Virchow JC, Canonica GW.   +3 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Factors associated with interferon-gamma release assay positivity in patients with psoriasis: a cross-sectional study. [PDF]

BMC Infect Dis
Song H, Zhang Y, Zhang Q, Zhang J, Gu W, Yang P, Xiao Y, Liu F, Li M, Ding W, Song K, Qiao L, Li Y, Ma Y.   +13 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Biologics in pediatric chronic rhinosinusitis with nasal polyps: A systematic review of efficacy and safety. [PDF]

Pediatr Allergy Immunol
Loperfido A, Anzivino R, Galletti C, Moffa A, Stivalini D, La Mantia I, De Corso E.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The BioSynIRS trial: biologic versus synthetic mesh for multicompartment pelvic floor reconstruction. [PDF]

Tech Coloproctol
Rudroff C, Halbe L, Schroer J, Ochel J, Daenenfaust L, Heidenreich A, Ludwig S.   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Real-World Phenotypic Profiles and Longitudinal Lung Function Outcomes in Severe Asthma Treated with Biologic Therapies. [PDF]

J Pers Med
Kotsiou OS, Barkas GI, Gourgoulianis KI, Daniil Z.   +3 more
europepmc   +1 more source

Consistent adherence to biologic therapies is critical for improving outcomes in asthma. [PDF]

J Allergy Clin Immunol Glob
Lugogo NL, Modena B, Kwiatek J, Wang J, Howarth P, Al-Lehebi R, Vichiendilokkul A, Karsanji U, Hwee J, Smith G, Geason R, Deb A, Alfonso-Cristancho R.   +12 more
europepmc   +1 more source