Results 111 to 120 of about 2,836,469 (290)
Potato Glykoalkaloids: Properties and Biological Activities
Atatürk Üniversitesi Ziraat Fakültesi Dergisi, 2022 Fatma Zehra OK, Arif ŞANLI
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Chemical similarity and biological activities
Journal of the Brazilian Chemical Society, 2002 "Similar molecules exert similar biological activities". Since long, medicinal chemists use this concept to modify the structures of biologically active compounds. Bioisosteric replacements of atoms and groups pave the way from various lead structures to
Kubinyi Hugo
doaj
Radiation protection for manned space activities [PDF]
The Earth's natural radiation environment poses a hazard to manned space activities directly through biological effects and indirectly through effects on materials and electronics.
Jordan, T. M.
core +1 more source
Biologically‐Active Gold(III) Complexes [PDF]
Metal-Based Drugs, 1998 A review is given of the background to and results of the succesful pharmacological testing of [AuX2(damp)] (X = Cl, OAc; damp = 2 − Me2NCH2C6H4) against a range of microbes, fungi and tumouts, culminating in in vivo xenografts of ZR‐1‐75. These are the first fully evaluated gold(III) complexes.
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Life fingerprints of nuclear reactions in the body of animals [PDF]
, 2010 Nuclear reactions are a very important natural phenomenon in the universe. On the earth, cosmic rays constantly cause nuclear reactions. High energy beams created by medical devices also induce nuclear reactions in the human body.
Ci-yi Liu +8 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source