Results 31 to 40 of about 403,543 (242)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of Microbiology & Biology Education, 2020 We designed a 16-week scaffolded student-scientist curriculum using inquiry-based research experiences integrated with professional development activities.
Porché L. Spence +4 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
PROGRAM and PROCEEDINGS THE NEBRASKA ACADEMY OF SCIENCES -- April 22, 2022 [PDF]
, 2022 Aeronautics & Space Science -- Chairperson(s): Dr. Scott Tarry & Michaela Lucas ANTHROPOLOGY SECTION Chairperson: Dr. Taylor Livingston APPLIED SCIENCE & TECHNOLOGY SECTION Chairperson: Mary Ettel BIOLOGICAL SCIENCES SECTION Chairperson: Therese McGinn ...
Nebraska Academy of Sciences
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
First steps in the implementation of a quality management sys-tem in the medical university
Archivo Médico de Camagüey, 2019 Background: a quality management system provides the organizational structure, the processes, procedures and tools to implement the necessary activities to achieve the objectives and quality requirements.
Cira Cecilia León-Ramentol +5 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
F1000Research, 2020 We report on the activities of the 2015 edition of the BioHackathon, an annual event that brings together researchers and developers from around the world to develop tools and technologies that promote the reusability of biological data.
Rutger A. Vos +76 more
doaj +1 more source