Results 121 to 130 of about 10,083,181 (394)

Don't Fall for Tuning Parameters: Tuning-Free Variable Selection in High Dimensions With the TREX

, 2015
Lasso is a seminal contribution to high-dimensional statistics, but it hinges on a tuning parameter that is difficult to calibrate in practice. A partial remedy for this problem is Square-Root Lasso, because it inherently calibrates to the noise variance.
Lederer, Johannes, Müller, Christian
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Values of inland fisheries in the Mekong river basin [PDF]

This report provides an overview of the biological, economical, social and cultural values of river fisheries in the Lower Mekong Basin (Yunan, Laos, Thailand, Cambodia and Vietnam). The report also identifies the main impacts of environmental changes on
Baran, E., Chong, C.K., Jantunen, T.
core  

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Fuzzy Aspects Associated with Biological Inheritance

Mathematics
Genetics explores the mechanisms of heredity and trait variation across organisms, with foundational principles established by Gregor Mendel through experiments on monohybrid and dihybrid crosses. The mathematical framework of hypergroups can effectively
Andromeda Pătraşcu Sonea
doaj   +1 more source

Chemical and biological aspects of octocorals from the Brazilian coast

, 2014
This review explores the chemical and biological aspects/results reported in the literature of the octocoral species collected at the Brazilian Coast. This article summarizes the biological activities (including pharmacological, antifouling and others ...
Maria Tereza R. Almeidaa, Maria Izabel G. Moritza, Katia C. C. Capelb, Carlos D. Pérezc, Eloir P. Schenkela   +4 more
semanticscholar   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Editorial: Biological aspects of bone marrow failure. [PDF]

Front Oncol, 2023
Diamantopoulos P, Avagyan S, Solomou E.
europepmc   +1 more source

Machine learning-guided directed evolution for protein engineering [PDF]

, 2019
Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying ...
Arnold, Frances H., Wu, Zachary, Yang, Kevin K.   +2 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source