Results 201 to 210 of about 2,906,575 (298)

Phenotype, subphenotype, and endotype in sepsis and ARDS: a new layer of heterogeneity? [PDF]

Crit Care
Zhao L, Zhao C, Wang M, Huang W.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Assessing the effects of limited vaccine supply on risk-based vaccination strategies in regions of endemic foot-and-mouth disease

Guyver-Fletcher G, Tildesley M.
europepmc   +1 more source

Real-World Multimodal Machine Learning for Risk Enrichment Across the Alzheimer's Disease Spectrum. [PDF]

J Clin Med
Bülbül NG, Baytaş İM, Kavalcı E, Karasu E, Okcu Korkmaz BC, Belen BG, Musaoğlu İS, Övüt AR, Arslanoğlu NE, Urhan M, Mutlu H, Özdağ MF.   +11 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Mechanistic synergy of biochar, phosphate-solubilizing microbes and MgO nanoparticle enhances phosphorus availability, soil fertility, and crop resilience in phosphorus-fixing soils (Oxisols). [PDF]

BMC Plant Biol
Li Q, Xu K, Ning Y, Duan H, Imran.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Explainable drug side effect prediction in central neural system via biologically informed graph neural network. [PDF]

Transl Psychiatry
Huang T, Lin KH, Machado-Vieira R, Soares JC, Jiang X, Kim Y.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Negative trial but positive lesson: reframing immunotherapy resistance from one-size-fits-all to precision strategies. [PDF]

BMJ Oncol
Jiang Y, Xu Y, Xia Y.
europepmc   +1 more source