The multifaceted roles of PI3Kγ in hypertension, vascular biology, and inflammation [PDF]
PI3Kγ is a multifaceted protein, crucially involved in cardiovascular and immune systems. Several studies described the biological and physiological functions of this enzyme in the regulation of cardiovascular system, while others stressed its role in ...
Carnevale, Daniela +2 more
core +2 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Extravascular factor IX after gene therapy in hemophilia B, does it matter?
Gene therapy will very likely change the treatment paradigm of hemophilia B in the coming years. For the majority of patients, adjunctive exogenous factor (F)IX clotting factor concentrate will continue to be needed in case of surgery or bleeding ...
Quentin Van Thillo, Cédric Hermans
doaj +1 more source
Heathland Restoration Techniques: Ecological Consequences for Plant-Soil and Plant-Animal Interactions [PDF]
We compare the soil and plant community development during heathland restoration on improved farmland when achieved through soil stripping with that achieved through soil acidification.
Diaz, Anita +2 more
core +1 more source
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Economic and environmental analysis of the introduction of legumes in livestock farming systems [PDF]
Legumes in low input systems are becoming increasingly important. The socioeconomic implication of the adoption of novel legumes species has been assessed in sheep and dairy cattle grazing systems in Europe using a biological model which has been linked ...
Reveredo Giha, C +3 more
core
Alfalfa Snout Beetle, \u3ci\u3eOtiorhynchus Ligustici\u3c/i\u3e L. (Coleoptera: Curculionidae): Methods for Egg Collection and Larval Rearing [PDF]
The alfalfa snout beetle, Otiorhynchus ligustici L., is the most serious pest of alfalfa in northern New York State. Recent research efforts focused on the biological control of this insect require the availability of all life stages.
Neumann, Gabor +2 more
core +2 more sources
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Green manure crops for low fertility soils [PDF]
Organic crop production is growing, but crop yields are still below potential. The purpose of our project “Nutrients for higher organic yields (NutHY)” is to increase yields and resource efficiency in organic crop production by optimizing nutrient supply.
Hansen, Veronika +2 more
core

