Results 171 to 180 of about 59,987 (246)

Enhancing Blood Circulation With Epsilon‐Near‐Zero (ENZ) Materials via the Far‐Infrared Window of Human Skin

Advanced Science, EarlyView.
Epsilon‐near‐zero (ENZ) silicon carbide enables a selective far‐infrared emitter spectrally aligned with the human skin window around 10 µm for wavelength‐matched thermal therapy. In 25 within‐subject trials (50 hands) monitored by laser speckle contrast imaging, SiC increases blood perfusion by 30.2% versus a broadband graphite emitter while ...
Wen‐Teng Yao, Shan‐Chiao Yang, Ming‐Feng Tsai, Hsuen‐Li Chen   +3 more
wiley   +1 more source

Microbial metabolism amplified warming in three Phanerozoic hyperthermal events. [PDF]

Nat Commun
Wu Y, Song H, Chu D, Cui Y, Dal Corso J, Luo G, Song H, Tian L, Song H, Jia E, Tong J.   +10 more
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

Evaluation of the antimicrobial and NorA and MepA efflux pump inhibitory activity of a hydrazone derivative of hydralazine against Staphylococcus aureus. [PDF]

Arch Microbiol
Belém KSTG, Rocha JE, Bento AJM, Dias JML, Coutinho HDM, das Chagas Lima Pinto F, de Menezes RRPPB, da Silva ME, Marinho ES, Marinho MM, Dos Santos HS.   +10 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

A Review of Phytoplankton Sinking Rates: Mechanisms, Methodologies, and Biogeochemical Implications. [PDF]

Biology (Basel)
Zhu J, Cheng J, Zeng J, Zhang W, Liu C, Effiong KS, Hao Q.   +6 more
europepmc   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Sponge-Based Flow Control in Laminate Capillary-Driven Electrochemical Microfluidic Devices for Viscous Sample Analysis. [PDF]

Anal Chem
Araújo DAG, Baldo TA, Paixão TRLC, Henry CS.   +3 more
europepmc   +1 more source