Results 171 to 180 of about 22,922,261 (397)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Effector Cpe1 secreted by Trichoderma longibrachiatum induces plant disease resistance

Biological Control
Trichoderma longibrachiatum SMF2 is an important biocontrol fungus that can control pathogen through a variety of mechanisms, such as competition, antibiosis, and induction of plant disease resistance.
Xiaoting Wang, Wenya Chen, Jialin Zhang, Weishe Hu, Ming Li, Peibao Zhao, Aizhi Ren   +6 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Wolbachia: A biological control strategy against arboviral diseases

, 2016
Ipsita Mohanty, Animesha Rath, Namita Mahapatra, Rupenangshu K. Hazra   +3 more
openalex   +1 more source

Cognitive control dysfunction and abnormal frontal cortex activation in stimulant drug users and their biological siblings [PDF]

, 2013
Dana Smith, P. Simon Jones, Edward T. Bullmore, Trevor W. Robbins, Karen D. Ersche   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Field evaluation of Cryptolaemus montrouzieri (Mulsant) (Coleoptera: Coccinellidae) as biological control agent of the mealybug Delottococcus aberiae De Lotto (Hemiptera: Pseudococcidae)

, 2019
Jesica Pérez‐Rodríguez, James Rudolph Miksanek, Jesús Selfa, Victoria Martínez‐Blay, A. Soto, Alberto Urbaneja, Alejandro Tena   +6 more
openalex   +2 more sources

An updated and validated model for predicting the performance of a biological control agent for the oriental migratory locust

, 2023
Elizabeth A. Finch, Hongmei Li, Alex Cornelius, J. H. Styles, Joe Beeken, Yumeng Cheng, Guangjun Wang, Guiguang Qiu, Belinda Luke   +8 more
openalex   +1 more source

Nonlinear control of biological dynamical systems [PDF]

, 2020
Morrison, Megan J
core   +1 more source