Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Predation efficacy of Chrysoperla carnea on two economically important stink bugs
Larvae of the green lacewing Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae) are generalist predators feeding on a range of pests in agroecosystems. Little is known about the suitability of stink bugs as prey for lacewing larvae.
Olivier Hendrik Berteloot+4 more
doaj
Bioprospecting of four Beauveria bassiana strains and their potential as biological control agents for Anastrepha ludens Loew 1873 (Diptera: Tephritidae). [PDF]
Angel-Ruiz NA+6 more
europepmc +1 more source
Conservation biological control using selective insecticides – A valuable tool for IPM
J. Torres, A. Bueno
semanticscholar +1 more source
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Among the many ways arthropod pests may signal their whereabouts to natural enemies, the release of specific volatiles by either pests themselves or their infested host plants may represent some of the most valuable cues that dictate biocontrol agent ...
Serena Leo+3 more
doaj
Exploiting Plant-Natural Enemy Interactions: Selection and Evaluation of Plants for the Improvement of Biological Control. [PDF]
Cortez-Madrigal H.
europepmc +1 more source
Biological Control of the Plant Pathogens. [PDF]
Borriss R, Keswani C.
europepmc +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
Metarhizium mendonceae sp. nov.: An important biological control agent for insect pests. [PDF]
da Costa Silva JD+14 more
europepmc +1 more source