Results 221 to 230 of about 29,021,689 (318)

QSAR with random biological data

Journal of Pharmacy and Pharmacology, 1981
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Comparison of clinical and biological data between septic arthritis of the hip and those of the knee caused by Kingella kingae. [PDF]

J Pediatr Orthop B
De Marco G, Cochard B, Ramadani A, Gurbanov E, Di Laura Frattura G, Tabard-Fougère A, Gavira N, Steiger C, Dayer R, Ceroni D.   +9 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

BioRels' data infrastructure: a scientific schema and exchange standard to transform and enhance biological data sciences. [PDF]

Nucleic Acids Res
Wang J, Turney A, Murray L, Craven AM, Bragger-Wilkinson P, Dos Santos B, Martasek J, Desaphy J.   +7 more
europepmc   +1 more source

Kimberley Coastal Biological Oceanography Data - October 2013

Maintenance and Update Frequency: asNeeded<b>Credit</b><br/>Mark Rehbein (Point Of Contact)<b>Credit</b><br/>Miles Furnas (Co Investigator)Biological Oceanographic data collected during the October 2013 dry season A ...

core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An annotated checklist of the Tortricidae of the region of Murcia (Spain) with new records, distribution and biological data (Lepidoptera, Tortricoidea). [PDF]

Biodivers Data J
Garre MJ, Girdley J, Guerrero JJ, Rubio RM, Ortiz AS.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Multivariate Poisson lognormal distribution for modeling counts from modern biological data: An overview. [PDF]

Comput Struct Biotechnol J
Subedi S, Dang UJ.
europepmc   +1 more source