Results 91 to 100 of about 5,861,528 (330)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Ants cannot account for interpopulation dispersal of the arillate pea Daviesia triflora [PDF]

, 2009
• Estimating distances and rates of seed dispersal, especially long-distance dispersal (LDD), is critical for understanding the dynamics of patchily distributed populations and species’ range shifts in response to environmental change.
Gove, A.D., Aaron D. Gove, Enright, N.J., Krauss, S., Enright, Neal, Ben P. Miller, Lamont, B.B., He, T., Lamont, Byron, Miller, B.P., Miller, Ben, Gove, Aaron, Siegfried L. Krauss, Tianhua He, He, Tianhua, Neal J. Enright, Krauss, S.L., Byron B. Lamont   +17 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Spatial mechanisms promoting plant coexistence. the role of dispersal and competition [PDF]

, 2009
One of the great challenges in ecology is to explain how large numbers of plant species are able to coexist in natural communities. The role of spatial structure for maintaining plant coexistence has so far mainly been explored by theory.
Vogt, Deborah Ruth
core   +1 more source

How Important Is Informed Natal Dispersal for Modelling the Demographic and Genetic Effects of Environmental Variability?

Ecology and Evolution
Dispersal is a fundamental ecological process that influences population dynamics and genetic diversity and is therefore an important component of the models used to simulate population responses to environmental change.
Sam C. Banks, Ian D. Davies, Teigan Cremona, Hugh F. Davies, Alexander R. Carey, Geoffrey J. Cary   +5 more
doaj   +1 more source

Wind dispersal of alien plant species into remnant natural vegetation from adjacent agricultural fields

Global Ecology and Conservation, 2017
Knowledge regarding the seed dispersal of alien species is crucial to manage invasion risk in fragmented natural habitats. Focusing on wind dispersal, this study assessed the spatial and quantitative extents to which a remnant natural fen receives the ...
Chika Egawa
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Mathematical Modelling of Mosquito Dispersal in a Heterogeneous Environment. [PDF]

, 2012
Mosquito dispersal is a key behavioural factor that affects the persistence and resurgence of several vector-borne diseases. Spatial heterogeneity of mosquito resources, such as hosts and breeding sites, affects mosquito dispersal behaviour and ...
Chitnis, N., Penny, Melissa A, Chitnis, Nakul, Penny, M. A., Lutambi, A. M., Smith, Thomas, Lutambi, Angelina Mageni, Smith, T.   +7 more
core   +1 more source