Results 191 to 200 of about 7,103,771 (354)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The prebiotic emergence of biological evolution. [PDF]

R Soc Open Sci
Kocher CD, Dill KA.
europepmc   +1 more source

Chemical roots of biological evolution: the origins of life as a process of development of autonomous functional systems. [PDF]

Open Biol, 2017
Ruiz-Mirazo K, Briones C, de la Escosura A.   +2 more
europepmc   +1 more source

Directed evolution of colE1 plasmid replication compatibility: a fast tractable tunable model for investigating biological orthogonality

, 2022
Santiago Chaillou, Pinelopi-Eleftheria Stamou, Leticia L. Torres, Ana B. Riesco, Warren Hazelton, Vitor B. Pinheiro   +5 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Prediction of biological evolution following blood product transfusion during liver transplantation: the contribution of machine learning to decision-making. [PDF]

BMJ Health Care Inform
Duranteau O, Popoff B, Abels A, Lucidi V, Savier E, Blanchard F, Martinez T, Loi P, Germanova D, Demulder A, Creteur J, Tuna T.   +11 more
europepmc   +1 more source

Expression of Truncated Products at the 5′-Terminal Region of RIPK2 and Evolutive Aspects that Support Their Biological Importance [PDF]

Ulises Mancini Villagra, Bianca Rodrigues da Cunha, Giovana Mussi Polachini, Tiago Henrique, Ana Carolina Buzzo Stefanini, Tialfi Bergamin de Castro, Carlos Henrique Tomich de Paula da Silva, Olavo A. Feitosa, Érica E Fukuyama, Rossana Veronica Mendoza López, Emmanuel Dias‐Neto, Fábio Daumas Nunes, Patrícia Severino, Eloíza H. Tajara   +13 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

The virtue of innovation: innovation through the lenses of biological evolution. [PDF]

J R Soc Interface, 2015
Kell DB, Lurie-Luke E.
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source