The cosmological model of eternal inflation and the transition from chance to biological evolution in the history of life [PDF]
, 2007 Eugene V. Koonin
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Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.
Cancer Cell, 2015 N. Mcgranahan, C. Swanton
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Neutral Evolution in a Biological Population as Diffusion in Phenotype Space: Reproduction with Local Mutation but without Selection [PDF]
, 2007 Daniel J. Lawson, Henrik Jeldtoft Jensen
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Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
We Recognize Ourselves as Being Similar to Others: Implications of the “Social Brain Hypothesis” for the Biological Evolution of the Intuition of Freedom [PDF]
, 2007 Eckart Voland
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Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Evolution of Cell Recognition by Viruses: A Source of Biological Novelty with Medical Implications
, 2003 Éric Baranowski +4 more
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Once upon Multivariate Analyses: When They Tell Several Stories about Biological Evolution. [PDF]
PLoS One, 2015 Renaud S +4 more
europepmc +1 more source