Results 301 to 310 of about 1,911,773 (360)

Strong evidence for the evolution of decreasing compositional heterogeneity in SARS-CoV-2 genomes during the pandemic. [PDF]

Sci Rep
Oliver JL, Bernaola-Galván P, Carpena P, Perfectti F, Gómez-Martín C, Castiglione S, Raia P, Verdú M, Moya A.   +8 more
europepmc   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Genomic insights into the mechanisms of body size evolution in Serpentes. [PDF]

BMC Genomics
Xia T, Zhou S, Zhang Z, Wu X, Wang X, Ding J, Zhang L, Sun G, Yang X, Gao X, Zhang H.   +10 more
europepmc   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, Volume 19, Issue 5, Page 1299-1309, May 2025.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Embracing the systems complexity of microbial ecology and evolution: call for papers. [PDF]

mSystems
Bittleston L, Gilbert J, Klassen J, Mackelprang R, Mandel MJ, Newton RJ, Paudel A, Rodriguez-Verdugo A, Shade A, Wilhelm RC, Zhang Y.   +10 more
europepmc   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, Volume 19, Issue 5, Page 1452-1470, May 2025.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

The Significance of the Entropic Measure of Time in Natural Sciences. [PDF]

Entropy (Basel)
Martyushev LM.
europepmc   +1 more source

Reconstruction of Ancestral Protein Sequences Using Autoregressive Generative Models. [PDF]

Mol Biol Evol
De Leonardis M, Pagnani A, Barrat-Charlaix P.   +2 more
europepmc   +1 more source