Results 91 to 100 of about 4,859,991 (300)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Neuro Patterns Prior to Error Responses in Long-Lasting Working Memory Task: An Event-Related Potential Study

Frontiers in Behavioral Neuroscience, 2019
Few studies exist regarding the mechanism prior to response by which cognitive impairment may induce error in a single long-lasting task. The present study intends to clarify the changes in cognition at the electrophysiological level.
Yi Xiao, Jintao Wu, Jintao Wu, Jiaxuan Li, Jiaxuan Li, Weicai Tang, Feng Ma, Feng Ma, Chenhui Sun, Yuan Yang, Wenhao Zhan, Lizhi Wang, Huijong Yan, Fenggang Xu, Shanguang Chen   +14 more
doaj   +1 more source

Factors affecting ammonium uptake in streams - an inter-biome perspective [PDF]

, 2003
The Lotic Intersite Nitrogen experiment (LINX) was a coordinated study of the relationships between North American biomes and factors governing ammonium uptake in streams. Our objective was to relate inter-biome variability of ammonium uptake to physical,
Bowden, William B., Dahm, Clifford N., Dodds, Walter K., Findlay, Stuart, Gregory, Stanley V., Grimm, Nancy B., Hamilton, Stephen K., Johnson, Sherri L., Marti, Eugenia, McDowell, William H., Meyer, Judy L., Morrall, Donna D., Mulholland, Patrick J., Peterson, Bruce J., Tanks, Jennifer L., Thomas, Steven A., Valett, H. Maurice, Webster, Jackson R., Wollheim, Wilfred M.   +18 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effect of moderate-intensity continuous training and high-intensity interval training with astaxanthin supplementation on inflammatory factors of cardiac tissue in type 2 diabetic rats [PDF]

فصلنامه ابن سینا, 2021
Background and aims: The prevalence of diabetes has made necessary changes in lifestyle to prevent its complications. In this study, the effect of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) with staxanthin ...
Tohid Azizzadeh, Mohammad Reza Zolfaghari, Amir Fattahi, Kamal Khademvatani   +3 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Scientific experiments in the flight of the 1977 biological satellite (draft plan) [PDF]

The physiological, biological, radiobiological and radiophysical experiments planned for the 1977 biological satellite are described. The biological experiments will involve rats, higher and lower plants, insects and other biological specimens carried on

core   +1 more source

Extensions on the Twenty-Fifth Amendment: The Influence of Biological Factors on Assessments of Impairment [PDF]

, 2010
Because the framers of the Twenty-Fifth Amendment were so prescient in their creation of this legislation, it behooves subsequent scholars to examine additional potential concerns that would not have entered the debate forty years ago. Huge advances have
McDermott, Rose
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source