Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Natura 2000 Areas, Road, Railway, Water, and Ecological Networks May Provide Pathways for Biological Invasion: A Country Scale Analysis. [PDF]
Plants (Basel), 2021 Szilassi P +8 more
europepmc +1 more source
Correction: Long-term influence (1982–2023) of the introduced parasitoid Torymus sinensis (Hymenoptera: Torymidae) on the invasive pest, the chestnut gall wasp Dryocosmus kuriphilus (Hymenoptera: Cynipidae), at a starting point of the classical biological control in Japan [PDF]
, 2023 Seiichi Moriya +8 more
openalex +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Breathing space: deoxygenation of aquatic environments can drive differential ecological impacts across biological invasion stages. [PDF]
Biol Invasions, 2021 Dickey JWE +9 more
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Impacts of Single and Multiple Co‐Existing Invasive Species on Subtropical Native Ant Communities
Ecology and EvolutionBiological invasions pose a significant threat to ecosystem stability by altering the taxonomic and functional diversity of native communities. It is still uncertain, however, whether multiple invasive species have varying effects on native communities ...
Jiaxin Hu +3 more
doaj +1 more source
Recent biological invasion may hasten invasional meltdown by accelerating historical introductions
, 2005 Edwin D. Grosholz
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Editorial: The Genomics of Biological Invasion
Frontiers in Ecology and Evolution, 2021 Angela McGaughran +2 more
doaj +1 more source