Results 101 to 110 of about 2,395,315 (295)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Contributions to the National Status Report on Biological Invasions in South Africa

Bothalia: African Biodiversity & Conservation, 2017
South Africa has committed to producing a National Status Report on Biological Invasions by October 2017 and thereafter every three years. This will be the first status report at a national level specifically on biological invasions.
John R.U. Wilson, Mirijam Gaertner, David M. Richardson, Brian W. van Wilgen   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Nonlinearity of root trait relationships and the root economics spectrum

Nature Communications, 2019
Kong et al. use a global trait dataset of 800 plant species to examine the root economics spectrum in relation to root diameter, tissue density and root nitrogen concentration.
Deliang Kong, Junjian Wang, Huifang Wu, Oscar J. Valverde-Barrantes, Ruili Wang, Hui Zeng, Paul Kardol, Haiyan Zhang, Yulong Feng   +8 more
doaj   +1 more source

Geographical, socioeconomic, and ecological determinants of exotic plant naturalization in the United States : insights and updates from improved data [PDF]

, 2012
Previous studies on alien species establishment in the United States and around the world have drastically improved our understanding of the patterns of species naturalization, biological invasions, and underlying mechanisms. Meanwhile, relevant new data
Marcel Rejmanek, Jun Wen, Guo,Qinfeng, Wen, Jun, Guo, Qinfeng, Rejm\ue1nek, Marcel, Rejmánek, Marcel, Rejmanek,Marcel, Wen,Jun, Qinfeng Guo   +9 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Impacts of crustacean invasions on parasite dynamics in aquatic ecosystems: A plea for parasite-focused studies

International Journal for Parasitology: Parasites and Wildlife, 2017
While there is considerable interest in, and good evidence for, the role that parasites play in biological invasions, the potential parallel effects of species introduction on parasite dynamics have clearly received less attention.
Clément Lagrue
doaj   +1 more source

Dynamics of biological invasions and pathways over time: a case study of a temperate coastal sea

, 2017
Coastal and regional sea ecosystems suffer from several human-induced stressors, including human mediated bioinvasions. The Baltic Sea is generally considered to be susceptible to invasions by non-indigenous species (NIS). Out of the total of 132 NIS and
Florin, Ann-Britt,, Sveriges lantbruksuniversitet.   +1 more
core   +1 more source