Results 151 to 160 of about 2,395,315 (295)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Recent advances in availability and synthesis of the economic costs of biological invasions. [PDF]

Bioscience, 2023
Ahmed DA, Haubrock PJ, Cuthbert RN, Bang A, Soto I, Balzani P, Tarkan AS, Macêdo RL, Carneiro L, Bodey TW, Oficialdegui FJ, Courtois P, Kourantidou M, Angulo E, Heringer G, Renault D, Turbelin AJ, Hudgins EJ, Liu C, Gojery SA, Arbieu U, Diagne C, Leroy B, Briski E, Bradshaw CJA, Courchamp F.   +25 more
europepmc   +1 more source

Ethics of biological invasions [PDF]

, 2014
The Ethics of Biological Invasions Etika biologických invazí Řešitel: Adam Klimeš Vedoucí práce: prof. RNDr. Stanislav Komárek, Dr. Abstract There is a considerable attention ascribed to the phenomenon of biological invasions - to the fast spread of ...
Klimeš, Adam
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Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Unveiling the hidden economic toll of biological invasions in the European Union. [PDF]

Environ Sci Eur, 2023
Henry M, Leung B, Cuthbert RN, Bodey TW, Ahmed DA, Angulo E, Balzani P, Briski E, Courchamp F, Hulme PE, Kouba A, Kourantidou M, Liu C, Macêdo RL, Oficialdegui FJ, Renault D, Soto I, Tarkan AS, Turbelin AJ, Bradshaw CJA, Haubrock PJ.   +20 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Capacity of countries to reduce biological invasions. [PDF]

Sustain Sci, 2023
Latombe G, Seebens H, Lenzner B, Courchamp F, Dullinger S, Golivets M, Kühn I, Leung B, Roura-Pascual N, Cebrian E, Dawson W, Diagne C, Jeschke JM, Pérez-Granados C, Moser D, Turbelin A, Visconti P, Essl F.   +17 more
europepmc   +1 more source

Economic Incentives for Controlling Trade-Related Biological Invasions in the Great Lakes [PDF]

Ballast water from commercial ships engaged in international trade has been implicated as the primary invasion pathway in over 60 percent of new introductions of invasive alien species (IAS) in the Great Lakes since 1960.
Horan, Richard D., Lupi, Frank
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