Results 71 to 80 of about 100,656 (298)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Allelopathic Potential and Chemical Composition of Essential Oil from the Invasive Plant Acmella radicans

Agronomy
Acmella radicans (Jacquin) R.K. Jansen is a new invasive species recorded in Yunnan Province, China, and little is known about its allelopathic potential and allelochemicals.
Kexin Yang, Yunhai Yang, Xiaohan Wu, Fengping Zheng, Gaofeng Xu, Shaosong Yang, Guimei Jin, David Roy Clements, Shicai Shen, Fudou Zhang   +9 more
doaj   +1 more source

Socio-economic impacts and assessment biological invasions [PDF]

, 2006
Biological invasions have been object of ecological research for years. As one objective, natural scientists investigate the effects of invasive species on ecosystems and their functioning (Levine et al. 2003).
Binimelis Adell, Rosa, Born, Wanda, Monterroso, Iliana, Rodríguez-Labajos, Beatriz   +3 more
core  

Supporting proactive management in the context of climate change: Prioritizaing range-shifting invasive plants based on impact [PDF]

, 2020
Non-native, invasive plants are projected to shift their ranges with climate change, creating hotspots of risk where a multitude of novel species may soon establish and spread. The Northeast U.S. is one such hotspot. However, because monitoring for novel
Bradley, Bethany A, Laginhas, Brittany B., Rockwell-Postel, Mei   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Potential distribution and ecological impacts of Acmella radicans (Jacquin) R.K. Jansen (a new Yunnan invasive species record) in China

BMC Plant Biology
Background Acmella radicans (Jacquin) R.K. Jansen is a new invasive species record for Yunnan Province, China. Native to Central America, it has also been recently recorded invading other parts of Asia. To prevent this weed from becoming a serious issue,
Shicai Shen, Fengping Zheng, Wei Zhang, Gaofeng Xu, Diyu Li, Shaosong Yang, Guimei Jin, David Roy Clements, Emma Nikkel, Aidong Chen, Yuchen Cui, Zewen Fan, Lun Yin, Fudou Zhang   +13 more
doaj   +1 more source

A review of the influence of root-associating fungi and root exudates on the success of invasive plants [PDF]

, 2012
Plant-fungal interactions are essential for understanding the distribution and abundance of plants species. Recently, arbuscular mycorrhizal fungal (AMF) partners of non-indigenous invasive plants have been hypothesized to be a critical factor ...
Bongard, Cindy
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Knowing what we count : a comment on Guo [PDF]

, 2011
Guo (2011) points to problems arising from different approaches to estimating the proportions of floras that are native or alien, specifically those across and within various regions.
Pyšek, Petr
core   +2 more sources