How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Genome sequence of bacteriophage AmiCi24 isolated using Arthrobacter globiformis
AmiCi24 is a novel siphoviral bacteriophage that was isolated from a soil sample collected in Sewell, NJ, USA using Arthrobacter globiformis B-2979 as the host. AmiCi24 has a genome consisting of 38,466 base pairs that encodes 68 predicted protein-coding
Paige Baldwin +15 more
doaj +1 more source
Can Mathematics be Biology's next microscope in disease research at the interface?
In this paper we discuss how mathematics can be integrated into biological research as well as the benefits and challenges related to this process. The focus is on the research of diseases at the interface between wildlife, humans and livestock with some
Roumen Anguelov, Armanda Bastos
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Department of Applied Mathematics and Statistics newsletter, September 11, 2023
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...
core
Protocol for quantifying miRNA trafficking across the endosomal membrane
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Māori medium children’s views about learning mathematics: possibilities for future directions [PDF]
Pre-European traditional Māori education in New Zealand was integrated and holistic. With Western influence many Maori children struggled to achieve at school. Māori medium education based on retaining Māori values, language and culture therefore emerged
Taylor, Merilyn, Hāwera, Ngārewa
core
Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Assessing the role of online mathematics tools in enhancing student learning and engagement
As digital technology improves and educational standards rise, online tools for teaching mathematics are one of the advancements recorded in digital technologies.
Olajumoke Olayemi Salami +1 more
doaj +1 more source

