Results 101 to 110 of about 1,932,979 (312)
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Improved Learning Experience Memristor Model and Application as Neural Network Synapse
IEEE Access, 2019 This paper proposes a memristor model, named learning experience memristor (LEM), for using as synapse in the associative neural network. The properties of LEM are discussed under different external voltages.
Xiaohong Zhang, Keliu Long
doaj +1 more source
On the biological plausibility of orthogonal initialisation for solving gradient instability in deep neural networks [PDF]
, 2022 Nikolay Manchev, Michael Spratling
openalex +1 more source
Sound Recognition System Using Spiking and MLP Neural Networks [PDF]
, 2016 In this paper, we explore the capabilities of a sound classification system that combines a Neuromorphic Auditory System for feature extraction and an artificial neural network for classification.
Cerezuela Escudero, Elena +5 more
core
TopologyNet: Topology based deep convolutional neural networks for biomolecular property predictions
, 2017 Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered by the ...
Cang, Zixuan, Wei, Guo-Wei
core +2 more sources
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan +46 more
wiley +1 more source
All-Optical Assay to Study Biological Neural Networks
Frontiers in Neuroscience, 2018 We introduce a novel all-optical assay for functional studies of biological neural networks in vitro. We created a novel optogenetic construct named OptoCaMP which is a combination of a channelrhodopsin variant (CheRiff) and a red genetically encoded ...
Wardiya Afshar Saber +4 more
semanticscholar +1 more source
Multitasking associative networks
, 2012 We introduce a bipartite, diluted and frustrated, network as a sparse restricted Boltzman machine and we show its thermodynamical equivalence to an associative working memory able to retrieve multiple patterns in parallel without falling into spurious ...
Adriano Barra +8 more
core +1 more source
Moyamoya Disease and the Risk of Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by the progressive narrowing of arteries at the base of the brain, forming abnormal collateral vascular networks. While vascular parkinsonism is noted in MMD, its link to Parkinson's disease (PD) has not been explored.
Dallah Yoo +9 more
wiley +1 more source