Open and remotely accessible Neuroplatform for research in wetware computing
Frontiers in Artificial IntelligenceWetware computing and organoid intelligence is an emerging research field at the intersection of electrophysiology and artificial intelligence. The core concept involves using living neurons to perform computations, similar to how Artificial Neural ...
Fred D. Jordan +4 more
doaj +1 more source
Learning biological neuronal networks with artificial neural networks: neural oscillations
, 2022 First-principles-based modelings have been extremely successful in providing crucial insights and predictions for complex biological functions and phenomena. However, they can be hard to build and expensive to simulate for complex living systems. On the other hand, modern data-driven methods thrive at modeling many types of high-dimensional and noisy ...
Zhang, Ruilin +6 more
openaire +2 more sources
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Predicting protein secondary structure based on ensemble Neural Network
ITEGAM-JETIA, 2021 Protein structure prediction is very vital to innovative process of discovering new medications based on the knowledge of a biological target. It is also useful for scientifically exposing the biological basis of convoluted diseases and drug effects ...
Emmanuel Gbenga Dada +3 more
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Emergence of Synchronous Oscillations in Neural Networks Excited by Noise
, 2005 The presence of noise in non linear dynamical systems can play a constructive role, increasing the degree of order and coherence or evoking improvements in the performance of the system. An example of this positive influence in a biological system is the
FitzHugh +17 more
core +1 more source
Biological Motion induced mu suppression is reduced in Early Psychosis (EP) patients with active negative symptoms and Autism Spectrum Disorders (ASD). [PDF]
, 2016 There is evidence of genetic and neural system overlap in Autism Spectrum Disorder (ASD) and Early Psychosis (EP). Five datasets were pooled to compare mu suppression index (MSI), a proxy of mirror neuron activity, in EP, high functioning ASD, and ...
Cadenhead, Kristin S +4 more
core +1 more source
NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products
Journal of Natural Products, 2020 Computational approaches such as genome and metabolome mining are becoming essential to natural products (NPs) research. Consequently, a need exists for an automated structure-type classification system to handle the massive amounts of data appearing for
Hyun Woo Kim +11 more
semanticscholar +1 more source
A Biologically Plausible Neural Network for Multichannel Canonical Correlation Analysis [PDF]
Neural Computation, 2020 Cortical pyramidal neurons receive inputs from multiple distinct neural populations and integrate these inputs in separate dendritic compartments. We explore the possibility that cortical microcircuits implement canonical correlation analysis (CCA), an ...
David Lipshutz +4 more
semanticscholar +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source