Results 231 to 240 of about 70,455 (289)

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

NetCrafter: ontology-derived gene network modeling and functional interpretation. [PDF]

Brief Bioinform
Lee Y, Kim S, Park Y, Jeong E, Jeong S, Kim S, Shin J, Jeong E, Noh H, Yoon S.   +9 more
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Empowering biological knowledgebases: advances in human-in-the-loop AI-driven literature curation. [PDF]

Bioinform Adv
Wood V, Jeffryes M, Green AF, Blum M, Orchard S, Panni S, Quaglia F, Rodriguez-Esteban R, Seager J, Tosatto SCE, Wittig U, Harrison M.   +11 more
europepmc   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

SorghumBase: a knowledgebase for sorghum genomics, phenomics, and stakeholder engagement. [PDF]

Genetics
Gladman N, Olson A, Kumari S, Wei S, Chougule K, Lu Z, Tello-Ruiz MK, Van Buren P, Kumar V, Zhang L, Olson A, Kim C, Braynen J, Hayes C, Xin Z, Klein R, Rooney W, Provart N, Pasha A, O'Meara A, Shakoor N, Michael TP, Harrison M, Ware D.   +23 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Ontologies as the semantic bridge between artificial intelligence and healthcare. [PDF]

Front Digit Health
Ambalavanan R, Snead RS, Marczika J, Towett G, Malioukis A, Mbogori-Kairichi M.   +5 more
europepmc   +1 more source

AgBioDatabase Finder: an online tool to help researchers find and submit agricultural genomic, genetic, and breeding data. [PDF]

MicroPubl Biol
Cabugos L, Buble K, Daenzer J, Jung S, Main D, Marrano A, Molik D, Raciti D, Wright A, Yook K, Reiser L.   +10 more
europepmc   +1 more source

BioPortal: an open community resource for sharing, searching, and utilizing biomedical ontologies. [PDF]

Nucleic Acids Res
Vendetti J, Harris NL, Dorf MV, Skrenchuk A, Caufield JH, Gonçalves RS, Graybeal JB, Hegde H, Redmond T, Mungall CJ, Musen MA.   +10 more
europepmc   +1 more source