Results 271 to 280 of about 70,807 (316)

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Pre-Meta: priors-augmented retrieval for LLM-based metadata generation. [PDF]

Bioinformatics
Tinn P, Sørbø S, Jiang S, Voutetakis K, Giounis SM, Pilalis E, Papadodima O, Roman D.   +7 more
europepmc   +1 more source

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

Rooting for data: A FAIR research data management and data analysis environment for the PlantMicrobe research collaboration. [PDF]

PLoS Pathog
Dröst F, Eberhardt U, Wellmann A, Saker H, Pirkl S, Krinninger M, Klingl A, Kemen E, Kamal N, Hachinger S, Krüger J.   +10 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Database Release: PPSDB, a Linked Open Data Knowledge Base for Protist-Prokaryote Symbioses. [PDF]

J Eukaryot Microbiol
Seah BKB.
europepmc   +1 more source

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, EarlyView.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

Multivariate models using NULISAseq and plasma p-tau217 for staging Alzheimer's disease. [PDF]

Alzheimers Dement
Doecke JD, Stage E, Fowler C, Doré V, Boehm N, Kleinert C, Challagundla M, Feizpour A, Ward L, Fripp J, Masters CL, Rowe C, Bannon A.   +12 more
europepmc   +1 more source

Cultural competence in psychotherapy. [PDF]

World Psychiatry
Kirmayer LJ.
europepmc   +1 more source

Gene Ontology (GO) enrichment analysis of biological process, cellular component and molecular function terms associated to the genes sequenced in the A549 cDNA library with the human genome as a background. Thefirst 20 terms for each each, in decreasing order of associated genes are displayed.

Cécile Schimmich (21453229), Mathilde Gondard (21453232), Gregory Caignard (5650675), José-Carlos Valle-Casuso (21453235), Damien Vitour (288809), François Piumi (3557651)   +5 more
openalex   +1 more source